Introduction In patients with stage II endometrial cancer, a radical hysterectomy is recommended. Nevertheless, it is associated with complications such as longer operative time, greater blood loss, and post-operative urinary retention. Thus, a simpler hysterectomy can be done with adjuvant treatment to reduce local recurrence and with lesser postoperative morbidity. The aim of this study is to determine the impact of hysterectomy type on prognosis and the pattern of relapse in patients with stage II endometrial cancer.

Methods The study was approved by the Institutional Review Board; patient charts from the outpatient department of a tertiary hospital Section of Gynecologic Oncology of endometrial cancer patients with stage II disease from January 1, 2011 to December 31, 2020 were reviewed.

Results The recurrence-free survival was higher among patients who underwent intrafascial and extrafascial hysterectomies at 12- and 24 months. However, at 36 months, those in the radical hysterectomy group have better recurrence-free survival (66%). For patients who underwent intrafascial hysterectomy, the overall survival at 12 and 24 months were 100%. For the extrafascial hysterectomy group, at 12 and 24 months, 100% overall survival; 88.89% (CI 43.3–98.36) at 36 months. For the radical hysterectomy group, at 12, 24, and 36 months, 100% overall survival, respectively. At 36 months, the radical hysterectomy group has better overall survival.

Conclusion/Implications The result of the retrospective study proposes that patients with stage II endometrial cancer who underwent radical hysterectomy had fewer recurrences. The radical hysterectomy group has also better overall survival as compared to the extrafascial hysterectomy group.