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EP156/#642  Survival outcomes in advanced stage operable carcinoma endometrium: experience of surgical treatment at a tertiary care cancer centre
  1. Shweta Rai1,
  2. Upasana Palo2,
  3. Anik Ghosh2,
  4. Basumita Chakraborti2,
  5. Jagannath Mishra2,
  6. Subhashree Rout2,
  7. Santam Chakraborty3,
  8. Tapesh Bhattacharyya3,
  9. Joydeep Ghosh4,
  10. Somnath Roy4 and
  11. Jaydip Bhaumik2
  1. 1Mahamana Pandit Madam Mohan Malviya Cancer Center, Gynecologic Oncology, Varanasi, India
  2. 2Tata Medical Centre, Kolkata, Gynecologic Oncology, Kolkata, India
  3. 3Tata Medical Centre, Kolkata, Radiation Oncology, Kolkata, India
  4. 4Tata Medical Centre, Kolkata, Medical Oncology, Kolkata, India


Introduction There is a lack of consensus regarding the surgical management of advanced-stage endometrial cancer. We aim to look at survival outcomes of advanced-stage carcinoma endometrium, managed through surgery and adjuvant treatment.

Methods This was a retrospective study from a tertiary care cancer centre in India that included all women registered between 1st August 2011 and 31st January 2021 with operable advanced-stage carcinoma endometrium (stages 3 and 4). Their relevant data were collected from electronic medical records.

Results Out of 1760 endometrial cancer cases screened 102 women with stage 3 and 4 disease were operable. The mean age was 59 years. Most women were parous (85%) with an ECOG status of 0 or 1 (90%). Histopathology was high grade in 73 women (71.6%). Surgeries performed were: Staging surgery 50(49%), debulking surgery 38(37.2%), surgery after chemotherapy 6(5.8%). Eight women (7.8%) were operable but given only chemotherapy for various reasons. 72 (76.6%) patients received planned adjuvant treatment. Overall, 50 patients (56.8%) were upstaged after surgery. At the time of analysis, 32 (31.4%) women were alive without disease. Median disease-free survival of stage 3, stage 4 and both combined were 32.8 months (95%CI: 0–87), 19 months (7.6–30.3), and 23.5 months (95% CI: 13.7–33.2) respectively. Median overall survival was not reached for stage 3. For stage 4 and both combined, it was 41 months (95% CI: 18.8–63.1) and 50.1 months (95% CI: 31.2–69.1) respectively.

Conclusion/Implications Upfront surgery in advanced-stage endometrial carcinoma gives a respectable survival outcome after maximal surgical attempt.

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