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  • EP079/#533  The prevalence and distribution pattern of cervical high-risk HPV genotype infections among women with high-grade pre-invasive and invasive cervical cancer in Lagos, Nigeria

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AS03. Cervical cancer
EP079/#533  The prevalence and distribution pattern of cervical high-risk HPV genotype infections among women with high-grade pre-invasive and invasive cervical cancer in Lagos, Nigeria
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  1. Adeyemi Okunowo1,
  2. Adekunle Sajo2,
  3. Sunusi Garba3,
  4. Olufemi Thomas-Ogodo3,
  5. Austin Okoro3,
  6. Oluchi Ozonu4,
  7. Jane Ezeogbo4,
  8. Chinonso Egwuogu5,
  9. Roosevelt Anyanwu6,
  10. Ephraim Ohazurike3,
  11. Kehinde Okunade1 and
  12. Rose Anorlu1
  1. 1College of Medicine, University of Lagos/Lagos University Teaching Hospital, Department of Obstetrics and Gynaecology, Idi-Araba, Nigeria
  2. 2University of Pretoria, Department of Obstetrics and Gynaecology, Pretoria, South Africa
  3. 3Lagos University Teaching Hospital, Department of Obstetrics and Gynaecology, Idi-Araba, Nigeria
  4. 4Lagos University Teaching Hospital, Department of Nursing Services, Idi-Araba, Nigeria
  5. 5Lagos University Teaching Hospital, Department of Obstetrics and Gynaecology (colposcopy Unit), Idi-Araba, Nigeria
  6. 6College of Medicine, University of Lagos, Central Research Laboratory, Idi-Araba, Nigeria

Abstract

Introduction High-risk HPV (hr-HPV) has been identified as the key etiology in the development of high-grade pre-invasive and invasive cervical cancer (CIN2+/ICC). However, little is known about the distribution of cervical hr-HPV genotypes associated with CIN2+/ICC in Lagos, Nigeria. We sought to investigate the hr-HPV genotypes responsible for CIN2+/ICC in Lagos, Nigeria.

Methods The study was conducted as part of the Nigeria U54 study. DNA extract was obtained from cervical tissues obtained from women with confirmed CIN2+/ICC. Anyplex II HPV HR detection kit was used to detect the presence of 14 hr-HPV genotypes. Genotype-specific prevalence rates were computed and pattern of infection described.

Results The overall prevalence of hr-HPV infection was 91.1%. Hr-HPV 16, 18, 35, and 51 were the most common genotypes isolated with genotype-specific prevalence rates of 50.0%, 33.3%, 12.2%, and 7.8% respectively. Hr-HPV 39 (0.0%), 31 (1.1%), 68 (1.1%), 56 (2.2%) & 66 (2.2%) were the least prevalent genotypes. The prevalence of single and multiple hr-HPV infections were 55.6% and 35.6% respectively. 27.8% had dual hr-HPV infections, while 7.8% had ≥3 hr-HPV infections. Hr-HPV 16, 18, and 35 were the most prevalent genotypes seen in single (23.3%, 14.4% & 5.6% respectively) and multiple infections (26.7%, 18.9% & 6.7% respectively). Though the presence of hr-HPV 16 & 18 was associated with having multiple hr-HPV infections, it was not predictive of having it on multivariable analysis (P>0.05).

Conclusion/Implications Hr-HPV 16/18 remained a major cause of CIN2+/ICC, however, more attention needs to be given to hr-HPV 35 as an important cause of CIN2+/ICC.

https://doi.org/10.1136/ijgc-2023-IGCS.185

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