Introduction High-risk HPV (hr-HPV) has been identified as the key etiology in the development of high-grade pre-invasive and invasive cervical cancer (CIN2+/ICC). However, little is known about the distribution of cervical hr-HPV genotypes associated with CIN2+/ICC in Lagos, Nigeria. We sought to investigate the hr-HPV genotypes responsible for CIN2+/ICC in Lagos, Nigeria.
Methods The study was conducted as part of the Nigeria U54 study. DNA extract was obtained from cervical tissues obtained from women with confirmed CIN2+/ICC. Anyplex II HPV HR detection kit was used to detect the presence of 14 hr-HPV genotypes. Genotype-specific prevalence rates were computed and pattern of infection described.
Results The overall prevalence of hr-HPV infection was 91.1%. Hr-HPV 16, 18, 35, and 51 were the most common genotypes isolated with genotype-specific prevalence rates of 50.0%, 33.3%, 12.2%, and 7.8% respectively. Hr-HPV 39 (0.0%), 31 (1.1%), 68 (1.1%), 56 (2.2%) & 66 (2.2%) were the least prevalent genotypes. The prevalence of single and multiple hr-HPV infections were 55.6% and 35.6% respectively. 27.8% had dual hr-HPV infections, while 7.8% had ≥3 hr-HPV infections. Hr-HPV 16, 18, and 35 were the most prevalent genotypes seen in single (23.3%, 14.4% & 5.6% respectively) and multiple infections (26.7%, 18.9% & 6.7% respectively). Though the presence of hr-HPV 16 & 18 was associated with having multiple hr-HPV infections, it was not predictive of having it on multivariable analysis (P>0.05).
Conclusion/Implications Hr-HPV 16/18 remained a major cause of CIN2+/ICC, however, more attention needs to be given to hr-HPV 35 as an important cause of CIN2+/ICC.
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