Introduction Accurate target delineation is essential when using IMRT for intact cervical cancer. In 2011, RTOG published a consensus guideline using MR images. The goal of the current project is to expand on the previous atlas by including CT-based contours without and with PET±MRI registrations, to add common and complex scenarios, and to ask about simulation and treatment planning techniques.
Methods 28 experts contoured 3 cases, first on a non-contrast CT simulation scan, then with registered diagnostic images. The cases included (1) FIGO IIIC1 with a bulky tumor and a vaginal metastasis, (2) FIGO IIB with calcified uterine fibromas, and (3) FIGO IIIC2 with large lymph nodes. The contours were analyzed for consistency using an expectation-maximization algorithm for simultaneous truth and performance level estimation (STAPLE) with kappa statistics as a measure of agreement.
Results Analysis of the contours showed considerable agreement between experts in each of the cases with kappa statistics of 0.67–0.72. For each case, use of diagnostic PET±MRI was associated with an increase in volume. The largest increase was in the CTV primary for Case 2 (20% increase in average volume, 64% increase in STAPLE estimate volume), which may be due to variance in registration priorities. For the third case, 92.9% of participants increased their CTVs based on the addition of the PET scan.
Conclusion/Implications Here we show the value as well as the challenges of using co-registered diagnostic imaging. The main areas of variance remain determining the superior extent of CTV coverage, coverage of the mesorectum, simulation and planning protocols.
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