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Poster/ePoster Sessions
01. Cervical cancer
#878 Definitive radiotherapy/chemoradiotherapy results in geriatric patients with cervical cancer
Free
  1. Ilknur Alsan Cetin1,
  2. Hatice Halis2,
  3. Melis Gültekin3,
  4. Senem Alanyali4,
  5. sefika Arzu Ergen5,
  6. Kamuran Ibis6,
  7. Binnaz Sarper7,
  8. Zeliha Güzelöz8,
  9. Barbaraos Aydin9,
  10. Hatice Öner10,
  11. Dicle Arslan11,
  12. Candan Demiröz Abakay12,
  13. Enis Özyar13,
  14. Alpaslan Seraslan14,
  15. Havva Beyaz15,
  16. Aysenur Elmali16,
  17. Tugçe Bozkurt4,
  18. Seden Küçücük17,
  19. Nermin Mirzezade7,
  20. Ferah Yildiz3,
  21. Zeynep Özsaran4,
  22. Ilknur Bilkay Görken9 and
  23. Evrim Metcalfe18
  1. 1Marmara University Faculty of Medicine Radiation Oncology Department, Istanbul, Turkey
  2. 2Sakarya Training and Research Hospital, Sakarya, Turkey
  3. 3Hacettepe University Faculty of Medicine Radiation Oncology Department, Ankara, Turkey
  4. 4Ege University Faculty of Medicine Radiation Oncology Department, I?zmir, Turkey
  5. 5Istanbul University Cerrahpasa Medical Faculty Hospital Radiation Oncology Department, Istanbul, Turkey
  6. 6Istanbul University Medical Faculty Hospital Radiation Oncology Department, Istanbul, Türkiye
  7. 7Kocaeli University Medical Faculty Hospital Radiation Oncology Department, Kocaeli, Turkey
  8. 8Tepecik Training and Research Hospital, Department of Radiation Oncology, I?zmir, Turkey
  9. 9Dokuz Eylul University Faculty of Medicine Radiation Oncology Department, I?zmir, Turkey
  10. 10Aydin Atatürk State Hospital, Department of Radiation Oncology, Aydin, Turkey
  11. 11Erciyes University Faculty of Medicine Radiation Oncology Department, Kayseri, Turkey
  12. 12Bursa Uludag University Hospital Radiation Oncology Department, Bursa, Turkey
  13. 13Acibadem University Hospital Radiation Oncology Department, Istanbul, Turkey
  14. 14Ondokuz Mayis University Faculty of Medicine Radiation Oncology Department, Samsun, Turkey
  15. 15Ankara City Hospital Radiation Oncology Department, Ankara, Turkey
  16. 16Ministry of Health Elazig Fethi Sekin City Hospital, Elazig, Turkey
  17. 17Istanbul University Medical Faculty Hospital Radiation Oncology Department, Istanbul, Turkey
  18. 18Medipol University Medical Faculty Hospital Radiation Oncology Department, I?stanbul, Turkey

Abstract

Introduction/Background To investigate the prognostic factors for survival, the long-term results and toxicities in elderly (≥65years) patients with cervical cancer who underwent definitive radiotherapy/chemoradiotherapy with a cervical cancer diagnosis.

Methodology We reviewed the clinical records of 458 patients with cervical cancer .The median age was 71 (65–91). The median treatment dose was 50.4 Gy (45–64).Overall survival (OS), cancer-specific survival (CSS), disease-free survival (DFS), distant metastasis-free survival (DMFS), and local recurrence-free survival (LRFS) were evaluated using Kaplan-Meier, log-rank, and Cox regression analyses; p<0.05 was considered statistically significant.

Results Median follow-up 48 months (6 -243); The 5-year OS, CSS, DFS, DMFS, and LRFS were 61.6%, 77.5%, 75.6%, 81.1%, and 91.6%, respectively. OS, CSS, DFS, DMFS influencing factors performance status (PS) (p< 0.0001) in univariate analysis, tumor diameter (≤4cm, >4cm) (p= 0.004, p= 0.008, p< 0.0001) histopathology (squamous, adeno and others) (p= 0.001, p< 0.0001), presence of lymph nodes (LN) (p< 0.0001), treatment response (complete, partial, unresponsive) (p< 0,0001) was statistically significant. For OS, age (65–70, 71–79, ≥80) (p< 0.0001), type of treatment (CCRT, RT) (p< 0.0001), Brachytherapy (BT) application (p< 0.0001); BT application for CSS and DMFS (p= 0.025, p= 0.003) and treatment response for LRFS (p< 0.0001) were significant parameters. In multivariate analysis, independent prognostic factors for OS, CSS, DMFS, and DFS, are treatment response (p< 0.0001,p=0.003), LN ( p< 0.0001, p= 0.007, p= 0.002, p= 0.003) and PS for OS, DFS (p= 0.003, p= 0.004), the age for OS (p= 0.045), type of treatment (p< 0.0001). For DMFS, histopathology (p= 0.026) and BT application (p= 0.049) were found to be significant.

Conclusion Curative treatments for geriatric patients, especially in locally advanced cervical cancer, have a low rate of side effects but have a favorable effect on survival and definite CRT should be recommended in geriatric age.

Disclosures Curative treatments for geriatric patients, especially in locally advanced cervical cancer, have a low rate of side effects but have a favorable effect on survival and definite CRT should be recommended in geriatric age.

https://doi.org/10.1136/ijgc-2023-ESGO.200

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