Introduction/Background The incidence of cervical cancer in young women is increasing. This study aims to analyze the clinicopathological characteristics, treatment, and prognoses of women aged ≤40 years with locally advanced cervical cancer.

Methodology Medical record data of 25 locally advanced cervical cancer patients aged ≤40 years treated at Salah Azaiez Institute of Oncology between January 2010 and December 2020 were reviewed. The overall survival rate was estimated using the Kaplan–Meier method. Prognosis-related risk factors were analyzed using univariate analyses.

Results The median age at diagnosis in our study was 35.8 years ± 3.13. Among 25 patients, 24 (96%) were diagnosed with squamous cell carcinoma and 1 (4%) with adenocarcinoma. In 12 cases (48%), the FIGO stage was ≤ IIB and in 13 cases (52%) FIGO stage was >IIB. The median tumor size at diagnosis was 54.6mm ± 17.37. 24% of patients had multiple sexual partners. Only 15 patients were treated with curative intentions. 3 patients presented locoregional recurrence. No patient presented metastatic recurrence. 7 patients presented progression during treatment. 17 cases of death during follow-up were noticed among 25 cases.

One-year disease-free survival (DFS) was 67.2%. lymphovascular space involvement (LVSI) (p=0.010) was a prognostic factor that affected disease-free survival. DFS was not significantly different for tumor size (p=0.0179), cell type (p=0.5) histological grade (p=0.45), parametrial involvement (p=0.068), and pelvic lymph node metastases (p=0.155).

One-year overall survival (OS) was 46.7%. Parametrial involvement (p=0.001), FIGO stage (p=0.028), and histological grade were risk factors for poor prognosis for these patients. Os survival was not significantly different for tumor size, LVSI, and pelvic lymph node metastases.

Conclusion Locally advanced cervical cancer in young women presents an overall prognosis worse than in older patients.

Disclosures We have no potential conflict of interest to report