Introduction/Background Total pelvic exenteration (PE) is a radical operation, involving en bloc resection of pelvic organs, including reproductive structures, bladder, and rectosigmoid. PE is indicated in cases of unresponsive, recurrent pelvic cancer or for palliative intent. Careful patient selection and counseling are of paramount importance when considering someone for PE.

Methodology Between January 2011 and June 2022, 21 women underwent radical pelvic surgery (Exenteration) at Gyn-Oncological Department St. Luke’s Hospital in Thessaloniki, Greece. Data related to surgery, complications and outcomes were recorded.

Results Fifteen (15) patients underwent supra-levator anterior exenteration and 2 patients had combined LEER. Two (2) patients had supra-levator posterior exenteration and 4 patients infra-levator total exentaration. The 5 years Overall Survival was 52% (11 pts).

Conclusion PE is an alternative treatment in carefully selected cases with good oncological outcomes. It is crucial though to be performed in well-organized Oncological centers, by experienced and well trained surgeons.

Disclosures All authors declare no conflict of interest