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Poster/ePoster Sessions
01. Cervical cancer
#433 Impact of menopausal status on cervical dysplasias and cervical cancers
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  1. Ugur Kemal Ozturk1,
  2. Serkan Akis2,
  3. Esra Keles3,
  4. Cihat Murat Alinca1,
  5. Sefik Eser Ozyurek1 and
  6. Murat Api3
  1. 1University of Health Sciences, Zeynep Kamil Women and Children Diseases Education and Research Hospital, Department of Gynecologic Oncology, Istanbul, Turkey
  2. 2Marmara University Faculty of Medicine, Pendik Education and Research Hospital, Department of Gynecologic Oncology, Istanbul, Türkiye
  3. 3University of Health Sciences, Kartal Dr. Lütfi Kirdar City Hospital, Departmant of Gynecologic Oncology, Istanbul, Turkey

Abstract

Introduction/Background It is a matter of debate whether there are other factors that may affect the results of colposcopic biopsy independent of cytology and humanpapilloma virus (HPV) genotype results. Therefore, we evaluated the effect of age and reproductive status on clinical outcomes in patients who underwent colposcopy.

Methodology Patients who underwent colposcopic examination at department of Gynecological Oncology, between 2016 and 2020 were evaluated retrospectively. Patients with positive cervical cytology results or patients with unknown HPV type(s) were not considered. Only patients with HPV 16 positivity and normal smear results were evaluated. Patients who had previously undergone colposcopy or a diagnostic excisional procedure were excluded. Statistical analysis was performed using IBM SPSS for Windows, Version 25.0.

Results Of 404 patients, 317 (78.5%) were in the reproductive period and 87 (21.5%) were in the menopausal period. The mean age of reproductive-aged women was 38.4 ± 0.3, and the menopausal women was 54.7 ± 0.5. The incidence of biopsy-confirmed normal cervix, cervical intraepithelial neoplasia (CIN) 1, 2, 3 and cervical cancer were 242/404 (59.9%), 73/404 (18.1%), 31/404 (7.7%), 53/404 (13.1%), and 5/404 (1.2%), respectively (figure 1A). A significant statistical difference was found in the distribution between premenopausal and menopausal patients (p= 0.018). If we classify the biopsy results in 2 groups as CIN 1 and CIN 2+ (CIN 2 and more severe lesion or cancer); CIN 2+ was present in 78/239 (32.6%) of premenopausal patients and 11/76 (14.5%) of menopausal patients (p= 0.017, figure 1B). Cervical cancer in the menopausal period was not observed in our data.

Abstract #433 Figure 1
Abstract #433 Figure 1

a: The distrubution of biopsy-confirmed normal cervix, cervical intraepithelial neoplasia (CIN) 1, 2, 3 and cervical cancer Figure 1b: The number of cervical intraepithelial neoplasia (CIN) 2+ lesions among pre menopausal and menopausal patients

Conclusion The rate of low-grade cervical dysplasia is higher in menopausal patients with HPV 16 positive and normal cervical cytology compared to reproductive-aged patients.

Disclosures The authors have no potetial conflict of interest to report.

https://doi.org/10.1136/ijgc-2023-ESGO.143

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