Introduction/Background Brachytherapy can have significant side effects on a patient‘s quality of life. This study aims to assess their physical, emotional, social, and functional well-being.

Methodology A cross-sectional anonymous survey was conducted on 25 patients with gynecological cancer treated with brachytherapy in the last 3 months at Salah Azaiez Institute using two questionnaires, FACT-Cx and EORTC QLQ-C30.

Results The median age was 63 years (31–78). Thirteen patients (52%) received low-rate brachytherapy, while 12 patients (48%) received high-rate brachytherapy.

For physical well-being, the majority of patients did not experience extended bedridden periods (65%), lack of energy (35%), or need assistance with daily tasks (75%). However, 80% of patients reported difficulty meeting their family’s needs, and all patients required rest. Only six patients (24%) had difficulty sleeping.

Socially, 12 (48%) patients were satisfied with their communication with family and friends about their illness. Half of them reported that their physical condition or medical treatment interfered with their family and social life. Half of patients were afraid to have sex. In addition, 55% did not feel sexually attractive, and 85% were dissatisfied with their sex life.Emotionally, 70% of patients were nervous or worried about their condition, but 85% had not lost.

Financial difficulties related to medical treatment and physical condition were experienced by 60% of patients.

As for side effects, 25% of patients were bothered by vaginal odor, 35% experienced vaginal discharge or bleeding, and only 7 patients reported constipation or diarrhea.

The median rating of overall quality of life was 5 out of 7. The comparison of FACT-Cx scores between High-rate and Low-rate Brachytherapy revealed a mean average total score of 118 and 116, respectively.

Conclusion Brachytherapy may cause side effects affecting patients‘ quality of life. Healthcare professionals should manage outcomes and provide supportive care to maintain patient well-being.

Disclosures Nothing to disclose.