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#217 The role of human papillomavirus genotype in cervical intra-epithelial neoplasia screening
  1. Fariba Yarandi,
  2. Elham Shirali,
  3. Elham Feizabad,
  4. Somayyeh Parizan,
  5. Nasim Chitsaz,
  6. Zeinab Shakerardakani,
  7. Soheila Sarmadi,
  8. Sara Ramhormozian and
  9. Jafar Razavi Shirazi
  1. Tehran University of Medical Sciences, Tehran, Iran, Tehran, Iran


Introduction/Background Recent cervical cancer screening guidelines recommend complementary Pap smear test and colposcopy examination in patients with a positive high-risk human papillomavirus (HPV) test. This study aimed to evaluate the role of HPV genotype in colposcopy examination needed in cervical intra-epithelial neoplasia (CIN) screening.

Results In this study, 621 women were evaluated with a positive high-risk HPV (HPV-16 =184, HPV-18 =69, and HPV-others=368). From 184 positive HPV-16, 37 cases had CIN3+ (20%), which this rate was 8% in NILM, 20% in ASCUS, 15% in LSIL. Out of 69 positive HPV-18, 11 cases had CIN3+ (15.9%), which this rate was 4.7% in NILM, 10% in ASCUS, 16.6% in LSIL. Out of 368 HPV-others positive, only 7 cases had CIN3+ (1.9%), which this rate was 3.2% in NILM, with no case of CIN3+ in ASCUS, and LSIL.

Conclusion According to our findings, it seems colposcopy examination in patients with positive others high-risk HPV should be considered only in high-grade (ASCH, HSIL, and ACG) Pap smear results.

Abstract #217 Figure 1

The cervical intra-epithelial neoplasia risk according to the different HPV genotype and Pap smear results

Disclosures The authors indicate no conflict of interest.

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