Introduction/Background Recent cervical cancer screening guidelines recommend complementary Pap smear test and colposcopy examination in patients with a positive high-risk human papillomavirus (HPV) test. This study aimed to evaluate the role of HPV genotype in colposcopy examination needed in cervical intra-epithelial neoplasia (CIN) screening.

Results In this study, 621 women were evaluated with a positive high-risk HPV (HPV-16 =184, HPV-18 =69, and HPV-others=368). From 184 positive HPV-16, 37 cases had CIN3+ (20%), which this rate was 8% in NILM, 20% in ASCUS, 15% in LSIL. Out of 69 positive HPV-18, 11 cases had CIN3+ (15.9%), which this rate was 4.7% in NILM, 10% in ASCUS, 16.6% in LSIL. Out of 368 HPV-others positive, only 7 cases had CIN3+ (1.9%), which this rate was 3.2% in NILM, with no case of CIN3+ in ASCUS, and LSIL.

Conclusion According to our findings, it seems colposcopy examination in patients with positive others high-risk HPV should be considered only in high-grade (ASCH, HSIL, and ACG) Pap smear results.

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Abstract #217 Figure 1

The cervical intra-epithelial neoplasia risk according to the different HPV genotype and Pap smear results

Disclosures The authors indicate no conflict of interest.