Introduction/Background Cervical cancer (CC) is among the most common diagnosed cancer. Several genetic variants have been identified in ABCB1(RA1128503) region with the risk of developing several cancers. Here we explored the association of RS1128503 genetic variant in patients with cervical cancer.
Methodology Data in computer-based patient dossiers of MUMS were used to identify cervical cancer patients, between 2014 to 2018. DNAs were extracted and genotyping was performed by TaqMan real-time PCR. Logistic regression was used to assess the association between CC risk and genotypes.
Results Our data has been shown that the genotype frequency for rs1128503 of GG, AG and AA were 21.5, 62.7 and 15.6 in patient group while these values were 14.6,52.8 and 14.6 in healthy group, respectively. The distribution of genotype frequencies of polymorphism, was in Hardy-Weinberg equilibrium (HWE) (P>0.05) with MAF of 0.2. Our data showed patients with CC genotype was associated with the increased risk of developing cervical cancer (e.g., recessive genetic model, GG against AG+AA: OR=3.2, 95%CI:1.7–6.2, p<0.01). Also patients with GG genotype versus AA genotype had an high risk of developing CC (OR=5.9 : 2.4.14, p<0.01).
Disclosures We demonstrated the association of a genetic variant in ABCB1 gene with cervical cancer, indicating further investigation in a multi-center setting to assess the value of marker as a risk stratification marker in cervical cancer.
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