Introduction/Background Improved detection and treatment of gynecological tumors allowed for shifting the focus to the quality of life of affected patients, including their sexual health. The aim of this study was to investigate the impact of systematic lymphadenectomy on the sexual function of patients with endometrial cancer.

Methodology Between January 2010 and January 2022, n = 488 women with endometrial cancer underwent surgical treatment at Jena University Women’s Clinic. Of these, n = 341were invited to participate in the survey, and n = 299 women have provided feedback so far.

Results Out of the 299 respondents, n = 79 women completed the Female Sexual Function Index (FSFI). Among them, n = 30 women reported being sexually active. Mean age was 62.4 +/- 8.6 years and was not significantly different (p = 0.065, t-test) between women with (65.3 +/- 7.2 years) vs. without (59.5 +/- 9.1 years) systematic lymphadenectomy. The median overall FSFI score was 22.9 +/- 7.9. Women who underwent systematic lymphadenectomy had comparable (p = 0.833, t-test) mean overall FSFI score (21.7 +/- 7.2; n = 15) compared to those without systematic lymphadenectomy (22.3 +/- 8.9; n = 15).

Conclusion The study suggests that systematic lymphadenectomy in women with endometrial cancer does not have an impact on sexual function. Prospective studies with a larger number of patients are required to confirm these results.

Disclosures The authors have no potential conflict of interest to report.