Introduction/Background Endometrial cancer is the most common gynecologic cancer in high income countries and its incidence has been rising. The primary objective of sentinel lymph node (SLN) mapping in endometrial cancer is to identify the lymph nodes at risk for metastasis thus reducing the number of futile lymphadenectomies and its associated morbidities, moving towards precision medicine. To assure accuracy of staging it requires a high rate of SLN detection.

Methodology We present a case of a 67-year-old patient, that was diagnosed with a grade 3 endometrioid endometrial cancer. The patient underwent a robotic total hysterectomy with bilateral salpingo-oophorectomy and SLN dissection.

Results In this article with narrated video footage, we make a stepwise demonstration of the technique for finding and dissecting the sentinel lymph node, highlighting the importance of a thorough anatomical dissection and a profound knowledge of the main lymphatic drainage pathways in order to find the correct SLN.

Conclusion Knowledge of the main lymphatic drainage pathways is of paramount importance in endometrial cancer staging with SLN. Well preserved channels will allow for a clear identification of the true SLN, even when the SLN is detected in less common locations. Opening and developing pelvic spaces (paravesical and pararectal) are key to correctly identify the SLN.