Introduction/Background Endometrial cancer (EC) is the most common gynecological malignancy throughout the world. Sentinel lymph node biopsy with indocyanine green (ICG) has become more widely used and has been featured in recently published guidelines for EC.

Methodology A 45-year-old female with gravidity 0, parity 0, and body mass index 23.4 kg/m2 presented with complaints of abnormal uterine bleeding (spotting). Increased endometrial thickness was detected on transvaginal ultrasound (10 mm) in the postmenstrual period. Endometrioid type endometrial adenocancer with focal squamous differentiation International Federation of Gynecology and Obstetrics (FIGO) grade 1 was detected on endometrial biopsy.

Laparoscopic bilateral sentinel lymph node dissection with indocyanine green (ICG), hysterectomy (without uterine manipulator) + bilateral salpingo-oophorectomy were performed (video).

Results The patient stayed in hospital for 1 day. The final pathology result showed a FIGO grade 1, endometrioid type endometrial adenocancer with focal squamous differentiation, as a 1.5x 1 cm tumorous mass invading less than one-half of the myometrium. Neither lymphovascular invasion nor sentinel lymph node metastasis was detected.

Conclusion This video article is the first video demonstration of bilateral isolated high pelvic, para-aortic sentinel lymph node dissection in endometrial cancer.

Disclosures No major complications occurred during or after the surgery.