Introduction/Background Frailty is an underdiagnosed multidimensional age-related syndrome. Preoperative frailty assessment is recommended in the guidelines for cancer patients. This study aims to investigate the impact of a standardized, two-step, multidisciplinary evaluation of frailty on complications and prognosis in women with gynecological malignancies, surgically treated.

Methodology In this prospective clinical trial, women with all gynecological malignancies regardless of the previous treatments or the histological type who underwent surgery at the University Medical Centre Mainz from 02/2023 will be consecutively included. All participants undergo the two-step frailty assessment with selected screening tools (Screening I+II) and peripheral blood results and a comprehensive geriatric assessment (CGA).

The main outcome measures will be the relationship between perioperative laboratory results, intraoperative surgical parameters and the incidence of immediate postoperative in-hospital complications and the oncological prognosis with the preoperatively evaluated frailty-status.

Results This is an ongoing trail. So far, 133 patients were recruited for the study: 45 ovarian cancer (33.6%), 40 endometrial cancer (29.9%), cervical cancer 7 (5.2%), 31 vulvar and vaginal cancer (23.3%), as well as 10 others (7.5%).

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Abstract #222 Figure 1

Conclusion Frailty is a multidimensional, difficult quantifiable complex. To ensure a possible operationalization, we developed the two-step frailty assessment. This two-step frailty assessment identifies a significant proportion of non-frail patients and women who received optimization of their global health status to realize the standard operation.

Disclosures The authors declare no relevant conflict of interests.