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#780 Cervical cancer and pregnancy: cesarean section and radical histerectomy
  1. José María Mariconde,
  2. Otilio Daniel Rosato,
  3. Nestor Dicuatro and
  4. Hector Dante Lucchini
  1. Hospital Universitario de Maternidad y Neonatología, Córdoba, Argentina


Introduction/Background Cervical cancer diagnosed during pregnancy is the most challenging situation since the pregnant uterus itself is involved. Where possible, standard treatment is applied during pregnancy.

Methodology A 28-year-old patient at 33 weeks of pregnancy with unremarkable medical, surgical, or family history. Diagnosis of moderately differentiated invasive adenocarcinoma of the cervix. During prenatal care, in a small rural hospital at the time of 28 weeks‘ gestation she had presented with abnormal vaginal bleeding. An exophytic cervical tumor measuring 3 cm diameter with no evidence of parametrial or vaginal involvement was found on physical examination. (FIGO 2018 stage: IB2). The physical examination was consistent with the previously described tumor in the cervix measuring 3 cm in diameter. The pelvic MRI showed an intrauterine gestation with a tumor measuring 19×16 x 10 mm on the anterior lip of the uterine cervix. There was no evidence of lymph node involvement. In addition, there was no parametrial or vaginal compromise.

The case was discussed by the Tumor Committee that recommended expectant management awaiting fetal maturity at 36 weeks (with one single dose of betamethasone 12 mg) and a Cesarean-radical hysterectomy at the time of delivery. The pregnancy continued with no other complications.

Results At 36 weeks‘ gestation a Cesarean section was performed through a Cherney incision. A male child was delivered (Apgar 8/9, 2830 gm). After delivery, a type C1 radical hysterectomy (Morrow–Querleu) with pelvic lymphadenectomy and bilateral oophoropexy was performed.

Conclusion After 5 years the patient is free of desease and the child is healthy.

This kind of management requires a multidisciplinary approach and a center of reference in gynecology oncology.

Disclosures Cesarean section and radical C1 histerectomy is the option in this cases, performing the surgery at the same time.

The pathology report only describes five harvested pelvic lymph nodes. I would ask for a revision of the specimen and search for more nodes, since the most important anatomical landmarks for a bilateral pelvic lymphadenectomy were dissected, which should lead to a significant higher number of retrieved nodes. Therefore, indeed, postoperative IMRT is indicated to correct for an incomplete pelvic lymphadenectomy and to avoid pelvic sidewall recurrence.

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