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#1101 Diagnostic and therapeutic approach to vulvar cancer
  1. Asma Jellouli,
  2. Sirine Bayar,
  3. Haithem Aloui,
  4. Khaoula Magdoud,
  5. Mahdi Frikha,
  6. Mohamed Bedis Chennoufi and
  7. Hassine Saber Abouda
  1. Maternity and neonatology center of Tunis, Tunis, Tunisia


Introduction/Background Vulvar cancer is a rare disease, which represents 4% of gynecological tumors with an incidence of 0.5 to 1.5 per 100,000 women per year in France. Vulvar cancers are induced in 30 to 69% of cases by the presence of papillomavirus (HPV), in particular HPV 16 and 18, and can also occur in an inflammatory context. The diagnosis is made by histological examination of a vulvar biopsy. It usually affects older women and most often develops on a pre-existing dermatosis.

Methodology The aim of this work is to know the pre-cancerous and cancerous lesions in order to contribute to a better therapeutic approach.

Our study is a retrospective study of 10 cases of squamous cell carcinoma of the vulva collected over a period of 7 years.

Results The average age was 65.6 years with extremes ranging from 55 to 80 years. The time to consultation was very long with an average of 3.5 years.

Eighty percent of the patients had advanced tumors with an average size of 5.3 cm and in 80% of the case. Treatment was surgical in all cases, followed by radiotherapy in case of lymph node invasion and/or borderline vulvar resection. Overall survival at 5 years was 40%. The major prognostic factors were lymph node involvement and tumor size.s there were inguinal adenopathies.

Conclusion Vulvar cancer has a poor prognosis. The delay in diagnosis is a real problem despite the accessibility of the vulva. Only an earlier management is likely to improve the prognosis.

Management has evolved into a personalized multidisciplinary approach, where each therapeutic decision must be discussed in a multidisciplinary consultation meeting

Disclosures The information presented in this study is based on retrospective data and should be interpreted with caution. The findings and conclusions are specific to the study population and may not be generalizable to all cases of vulvar cancer.

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