Introduction/Background The coexistence of vaginal cancer and total uterine prolapse is quite rare. There is no consensus in the literature regarding the optimal treatment approach.

Methodology A retrospective case presentation of a patient with coexistence of vaginal cancer and total uterine prolapse will be presented in 2023 at Ondokuz Mayıs University, Samsun, Turkey

Results A 60-year-old female patient presented with total uterine prolapse and an ulcerated lesion in the vagina. Excisional biopsy of the lesion revealed grade 1 Squamous Cell Carcinoma unrelated to HPV. The patient underwent radical local vaginal excision, inguinofemoral lymph node dissection, vaginal hysterectomy and bilateral salpingo-oophorectomy, along with a Leforte colpocleisis. Histopathological examination of the tumor tissue from the vagina reported HPV-unrelated keratinizing-type grade 1 Squamous Cell Carcinoma with lymphatic invasion, perineural invasion and invasion into the muscle layer. The patient was referred to the Radiation Oncology department for radiation therapy planning.

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Abstract #905 Figure 1

Conclusion Based on the limited literature available on the treatment options for patients with the coexistence of total uterine prolapse and vaginal cancer, radiation therapy following vaginal surgical resection and reconstruction of the tumor is considered a feasible treatment option for these patients.

Disclosures There is no conflict of interest in this statement.