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#668 Evaluation of vulvar squamous cell and glandular cell cancers, retrospective multicenter study
  1. Kemal Güngördük1,
  2. Fuat Demirkiran2,
  3. Ghanim Khatip3,
  4. Murat Öz4,
  5. Yagmur Minareci Özgür Tosun2,
  6. Salih Taskin5,
  7. Levent Akman6,
  8. Varol Gülseren Bülent Özçelik7,
  9. Selen Dogan8,
  10. Yakup Yalçin9,
  11. Sükrü Çebi2,
  12. Dogan Vatansever10,
  13. Kemal Özarkan9,
  14. Cosan Terek6,
  15. Koray Aslan11,
  16. Muzaffer Sanci12,
  17. Firat Ortaç5,
  18. Mehmet Ali Vardar3,
  19. Ali Ayhan13 and
  20. Macit Arvas2
  1. 1Mugla Sitki Koçman University, Mugla, Turkey
  2. 2Istanbul University, Cerrahpasa Faculty of Medicine, I?stanbul, Turkey
  3. 3Çukurova University, Adana, Turkey
  4. 4Ankara City Hospital, Ankara, Turkey
  5. 5Ankara University, Ankara, Turkey
  6. 6Ege University, I?zmir, Turkey
  7. 7Erciyes University, Kayseri, Türkiye
  8. 8Akdeniz University, Antalya, Turkey
  9. 9Uludag University, Bursa, Turkey
  10. 10Koç University, Istanbul, Turkey
  11. 11Abdurrahman Yurtaslan Ankara Oncology Education and Research Hospital, Ankara, Turkey
  12. 12Tepecik Education and Research Hospital, I?zmir, Turkey
  13. 13Baskent University, Ankara, Turkey


Introduction/Background Carcinoma vulva is a rare disease accounting for 1.3% of all gynecological malignancies. The aim of the present study is to analyze the clinicopathological characteristics of women with squamous and glandular cell carcinoma vulva who underwent primary surgical management.

Methodology A retrospective analysis was conducted on 649 patients who were treated for squamous and glandular cell carcinoma of the vulva at a multicenter in Turkey.

Results The mean age of patients was 63.2 ± 12.8 years. The most common location for the disease was lateral (55.5%) and then midline (39.6%) and bilateral (0.6%). The surgical treatments for the primary tumor region were radical vulvectomy (80.1%) and simple vulvectomy (19.9%). The surgical margin was negative in 469 (72.3%) patients. The procedure of unilateral or bilateral inguinofemoral lymphadenectomy underwent respectively 77 (11.9%) and 453 (69.8%) patients. The mean number of lymph nodes dissected was 12.8 ± 7.2. The number of patients with lymph node metastasis was 247 (44.5%). Three hundred and eighty-eight cases were in FIGO stage I-II and 234 cases were in stage III. Postoperative adjuvant radiotherapy or chemoradiotherapy were required respectively for 165 (25.4%) and 141 (21.7%) patients. Recurrence developed in one hundred and seventy-three (26.7%) patients. Of these, 100 (15.4%) were local, 54 (8.3%) were inguinal lymph nodes, and 19 (2.9%) were multiple and/or distant. It was determined that the tumor size was larger (P= 0.017) and lymph node involvement was higher (P< 0.001) in those who developed recurrence. Also, it was detected that surgical margin status and histological subtype was effect statistically significant the recurrence rate.

Conclusion For patients with squamous and glandular cell carcinoma of the vulva, a surgical operation is the primary. Most important factors effecting recurrence are related to surgical quality.

Disclosures There is no potential conflict of interest (e.g., grant support, consultancy, membership on advisory councils, speaker’s bureau) and source of funding.

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