Introduction/Background Because of the significant consequences for women’s reproductive health, the interest for epidemiological, clinical and histopathological features of Gestational Trophoblastic Neoplasia is increasing. It is known that extreme ages are more frequent associated with the disease, so that, especially in teenagers, management and follow up represent a challenge.

Methodology This retrospective study assesses maternal characteristics, clinical presentation, tumor type, management and follows up of molar pregnancies managed in our third degree obstetric department of University Hospital of Oradea, from 1st January 2019 to 31st of December 2022.

Results More than 13000 deliveries were managed in this period in our hospital, also more than 1500 miscarriages being recorded and histopathological exam was performed in all of them. Gestational trophoblastic disease was diagnosed in 41 cases, 18 cases being teenagers. Fourteen from 18 cases were diagnosed in first trimester of pregnancy and we had only 4 second trimester pregnancies. Clinical and ultrasound exam showed a larger uterus than expected, but ovarian lutein cysts were not always present. Abnormal high values of beta HCG were always recorded. Histopathological exam after US guided aspirative curettage diagnosed 10 partial hydatidiform molar pregnancies, 7 cases of complete molar pregnancy and one choriocarcinoma and in this particular patient the oncologist’ s recommendation for chemotherapy was made. Follow up was the most difficult to manage properly in this very young group of patients, serial HCG blood values until normalization was possible in only two thirds of the girls.

Conclusion Early diagnosis, treatment and proper follow-up of this condition will lead to a good outcome in this very young group of patients. Unfortunately, follow-up in teenagers was quite a real challenge during these 4 years of the study.

Disclosures I do not have any conflict of interest with any person or organization.