Introduction/Background Among the psychological distresses encountered by survivors of gynecologic cancer, Fear of Cancer Recurrence (FCR) ranks high. This study, through a Meta-Analytic Structural Equation Modeling (MASEM) approach, offers an in-depth quantitative synthesis of significant predictors of FCR.

Methodology A meticulous literature search across databases such as PubMed, Embase, Cochrane Library, and Web of Science was conducted until January 2023. Studies addressing FCR predictors in women with gynecologic cancer survivorship were included. Associated factors were analyzed using the MASEM framework. The Newcastle-Ottawa Scale served as the tool for quality assessment of included studies.

Results Our analysis incorporated 35 studies with a sum of 5,698 participants. The MASEM unveiled that anxiety score (β = 0.56 CI 0.12 to 0.84, p < 0.01), and social support (β = 0.32 CI 0.09 to 0.66, p < 0.01) emerged as significant predictors of FCR, indicating that higher anxiety levels and inadequate social support can escalate FCR.

Conclusion This comprehensive meta-analytic review illuminates the critical role of anxiety and social support as significant determinants of FCR in women surviving gynecologic cancer. The findings underscore the necessity of incorporating psychological and social support interventions in post-treatment care plans to manage and mitigate FCR effectively.

Disclosures None