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Poster/ePoster Sessions
10. Quality of Life After Treatment
#208 Metabolic syndrome, long-term fatigue and inflammation in epithelial ovarian cancer survivors: vivrovaire, ancillary study
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  1. Pauline Desbois1,
  2. Zoe Neviere1,
  3. Brigitte Le Mauff2,3,
  4. Mohammed Sali Dauda4,
  5. François Gernier4,5,
  6. Jean-Michel Grellard4,
  7. Patricia Pautier6,
  8. Elsa Kalbacher7,
  9. Anne Floquet8,
  10. Dominique Berton-Rigaud9,
  11. Sophie Abadie-Lacourtoisie10,
  12. Olivier Tredan11,
  13. Christine Rousset-Jablonski12,
  14. Philippe Follana13,
  15. Jerome Alexandre14,
  16. Alain Zanetti15,
  17. Nadine Dohollou16,
  18. Benedicte Clarisse4,
  19. Florence Joly1,5,17 and
  20. François Cherifi1,18
  1. 1Department of Oncology, Centre François Baclesse, Caen, France
  2. 2Laboratory of Immunology, Department of Biology, Caen University Hospital, Caen, France
  3. 3Normandie Université, UNICAEN, Caen, France
  4. 4Department of Clinical Research, Centre François Baclesse, Caen, France
  5. 5INSERM, U1086, Caen, France
  6. 6Department of Oncology, Gustave Roussy, Villejuif, France
  7. 7Department of Oncology, CHU Jean Minjoz, Besançon, France
  8. 8Department of Oncology, Institut Bergonie, Bordeaux, France
  9. 9Department of Oncology, Institut de Cancérologie de l’Ouest, Site René Gauducheau, Saint Herblain, France
  10. 10Department of Oncology, Institut de Cancérologie de l’Ouest, Site Paul Papin, Angers, France
  11. 11Department of Oncology, Centre Léon Bérard, Lyon, France
  12. 12Departement of Surgery, Centre Léon Bérard, Lyon, France
  13. 13Department of Oncology, Centre Antoine Lacassagne, Nice, France
  14. 14Department of Oncology, Hôpital Cochin, Paris, France
  15. 15Department of Oncology, Centre Hospitalier de Cholet, Cholet, France
  16. 16Department of Oncology, Polyclinique Bordeaux Nord Aquitaine, Bordeaux, France
  17. 17University of Caen Normandy, UMR-S1077, Caen, France
  18. 18Department of Oncology, Jules Bordet, Bruxelles, Belgium

Abstract

Introduction/Background Quality of life (QOL) after treatments, notably long-term fatigue (LTF) is a major concern for epithelial ovarian cancer survivors (EOCs). Metabolic syndrome (MetS) was shown to be associated with cancer survivorship and fatigue. Inflammation was also demonstrated to be related with fatigue in cancer patients, but few studies explored LTF. We aimed to evaluate the association between LTF, MetS and inflammation among EOCs.

Methodology The VIVROVAIRE study enrolled EOCs free of relapse ≥ 3 years after treatments in 11 French GINECO centers. Fatigue was assessing using FACIT-F-TOI (including fatigue and physical/functional dimensions of the FACT-G) self-questionnaires. MetS was estimated by the International Diabetes Federation definition. Blood cytokines (IFN-γ, IL-10, IL-18, IL1-RA, IL-6, IL-8, IL1-β and TNF-α) were measured by enzyme-linked immunosorbent assay. Univariate, multivariate regression analyses and mediation analysis were performed, with a statistical significant of p ≤ 0,01.

Results Analyses concern 143 EOCs: median age at inclusion, 63 years [range, 55–70], median delay from end of treatment, 5 years [range, 3–7]. Prevalence of MetS was 22% (31 patients). EOCS with MetS had poorer FACIT-F-TOI score than non-MetS EOCS (75 vs 87, p = 0.001). Elevation of IL1-RA and IL-6 expressions was significantly associated with MetS in univariate (p <0.001 and p = 0.002, respectively) and multivariate regression analyses (p <0.001 and p = 0.008).

IL1-RA was also associated with the FACIT-F-TOI in uni and multivariate analysis (p <0,001). The mediation analysis performed showed IL1-RA produced an average causal mediation between FACIT-F-TOI score and MetS (p = 0,008) with a significant proportion of mediated effect (41%, p = 0,01).

Conclusion EOCs with MetS present more LTF than to EOCs without MetS. Inflammation was associated with MetS and LTF with causal relation. Inflammation could play a role in persistent fatigue and interventions to reduce MetS may help to improve LTF.

Disclosures None

https://doi.org/10.1136/ijgc-2023-ESGO.749

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