Introduction/Background After the failure of Human Papilloma Virus (HPV) the vaccination campaign in 2018 in Romania, a new campaign has begun in 2021 with nonavalent HPV vaccine. Our study assessed the knowledge, attitudes, and practice of involved groups towards HPV infection and vaccination in Northeastern part of Romania.

Methodology Semi-structured interviews with teens, key informants comprising of parents, teachers, community leaders and health professionals involved in HPV were conducted. Thematic content analysis was used for data analysis.

Results From our findings, a significant proportion of teens, have limited knowledge of the subject. Vaccination of boys is viewed with suspicion by the parents and even teachers. However, the parent’s attitudes are better now than in the first campaign, when the parent’s rejection was the main reason for the failure of the campaign. A more positive attitudes was also observed among general practitioners and nurses. A potential problem that can affect the vaccination is the long waiting time to obtain the vaccine.

Conclusion This second HPV campaign started from much higher premises compared to the failed campaign of 2008. Active involvement in primary prevention strategies may promote the uptake of the vaccine encouraging the acceptability of vaccination.

Disclosures No disclosures.