Introduction/Background Risk-reducing bilateral oophorectomy and salpingo-oophorectomy (RRSO) lowers the risk of developing ovarian cancer (85–90%) and breast cancer (40–70%) in women with BRCA1/2 mutation. The aim of the work is to analyse the issues of prophylactic adnexectomy in Opole Oncology Center years 2017–2023.

Methodology Retrospective data analysis

Results Prophylactic laparoscopic adnexectomy was performed on 44 patients (average age - 49.4 years). Cancer was accidentally detected in 3 patients (6.5%). RRSO at the age of 60 (only one with Ca 125 increased to 69U/ml, fallopian tube cancer, RRSO at the age of 65 and RRS patient aged 48 - borderline tumour. No cancer was detected in any of the 28 patients including those with cancer during prior pelvic MRI. Most of the patients (26) performed prophylactic adnexectomy after breast cancer. Average age of procedure for both groups was 49,4. Average age of genetic tests in those patients was 45 (whole group - 43.6 years) and average cancer development was 42,4. Two out of 18 patients without family history developed breast cancer after RRSO at ages 40 and 48. None of the patients had STIC (serous tubal intraepithelial carcinoma). One patient had a conversion to laparotomy due to bleeding, which sets complication rate at 2.2%.

Conclusion The recommended age for RRSO is 35–40 years of age. Later, there is a greater risk of developing ovarian cancer confirmed by our analysis. MR and Ca 125 of the pelvis performed before surgery did not increase cancer detection sensitivity. We need standardized evaluation criteria pre-operatively to determine the risk of incidental cancer. Selection is necessary for young patients who have indications for genetic testing which makes prophylactic adnexectomy possible to be performed before the age of 40. RRSO rarely carriesa risk of complications (0.22–4%) – which was confirmed in our analysis.

Disclosures We have no potential conflict of interest to report