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#99 Effectiveness of photodynamic therapy with photosensitizer photolon in 150 women with cervical high-grade squamous intraepithelial lesion
  1. Olga P Matylevich,
  2. Tatsiana P Artsemyeva,
  3. Dmitry A Tzerkovsky and
  4. Oksana A Erochina
  1. NN Alexandrov National Cancer Centre of Belarus, Minsk, Belarus


Introduction/Background Photodynamic therapy (PDT) is a minimally-invasive and high efficacy treatment for cervical intraepithelial neoplasia (CIN). The objective of the present study was to evaluate an organ-saving approach for the treatment of CIN using PDT with the chlorine-based photosensitizer (PS) applied in women with cervical high-grade squamous intraepithelial lesions (HSIL).

Methodology A total number of 150 patients aged 21–77 with morphologically proven diagnosis of HSIL were enrolled into the study. Photoirradiation with laser light at a wavelength of 665±5 nm was applied to the uterine cervix (100–130 J/cm2, 0.083–0.17 W/cm2) and endocervical canal (50–100 J/cm2, 0.083–0.17 W/cm2) of patients 2.5–3 hours after an intravenous injection of 2–2.5 mg/kg of PS «Photolon». Adverse events were assessed within 1 month after treatment. The main outcome measure was efficacy, defined as complete cytologic remission in 3 and 6 months after PDT.

Results Side effects were mild, the most common complaints were pain in the first days after irradiation and an increase in body temperature up to 37.0–37.8°C. A complete response, represented by a complete regression of tumor lesions, confirmed 3 and 6 months after treatment by the results of a morphological study, was detected in 94.4 and 86.8% of treated women, respectively. Relapses of the disease during the follow-up period from 7 months to 3 years were detected in 5.3% of cases.

Conclusion PDT can be a safe and efficient organ-preserving treatment in patients with cervical HSIL. PDT did not appear to create cervical damage and have negligible side effects.

Disclosures Authors have no any disclosures.

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