Article Text
Abstract
Introduction/Background Sertoli-Leydig cell tumor is a mesenchymal and sex cord derived tumor differentiating in the testicular direction.This tumor has in most cases endocrine functions, and its prognosis is significantly correlated to its degree of differentiation.Accurate diagnosis and knowledge of prognosis based on clinical and pathological features have important therapeutic implications.
Methodology Through the observation of a patient with Sertoli-Leydig cell tumor and a review of the literature, we tried to identify the main diagnostic and prognostic features.
Results Mrs.
TA, 31 years old, operated on for a benign nodule of the left breast, with no cycle disorder or signs of virilization and with well-developed secondary sexual characteristics, who was found on ultrasound, as part of the exploration of her 1-year primary infertility, a 3 cm solid cystic septated tumor of the right ovary, persistent. The dosage of CA 125, CEA and alpha-feto protein were not elevated. A laparoscopic intraperitoneal cystectomy was performed with peritoneal cytology. Histological and immunohistochemical examination concluded to a well-differentiated sertoli cell tumor. The operation was completed by a right adnexectomy. Two months later, the anatomopathology did not reveal any tumor recurrence. Postoperative monitoring, a reference biological workup including the dosage of DHEA-S, estrogen, testosterone, 17 hydroxy-progesterone and cortisol came back normal. The last clinical, ultrasonographic and biological controls carried out every three months, after a 1-year follow-up, did not show any recurrence.
Conclusion In the presence of pelvic pain associated with signs of hyperandrogenism, the diagnosis of a Sertoli-Leydig cell ovarian tumour should be considered. Pelvic ultrasound reveals an unilateral pelvic tumour, of solid cystic type. This tumor has a low malignant potential. Its treatment is based on surgery, which ranges from conservative treatment, justified in young women, to radical treatment indicated in advanced stages and in the presence of poor prognostic risk factors, which sometimes indicates adjuvant chemotherapy.
Disclosures The findings are specific to the study population and may not be generalizable to all ases of this type of tumor.