Article Text

Download PDFPDF

#1098 Study of the diagnostic and prognostic characteristics of ovarian sertoli-leydig cell tumors
Free
  1. Asma Jellouli,
  2. Sirine Bayar,
  3. Haithem Aloui,
  4. Abir Karoui,
  5. Khaoula Magdoud,
  6. Mahdi Farhati,
  7. Mohamed Bedis Channoufi and
  8. Hassine Saber Abouda
  1. Maternity and Neonatology Center of Tunis, Tunis, Tunisia

Abstract

Introduction/Background Sertoli-Leydig cell tumor is a mesenchymal and sex cord derived tumor differentiating in the testicular direction.This tumor has in most cases endocrine functions, and its prognosis is significantly correlated to its degree of differentiation.Accurate diagnosis and knowledge of prognosis based on clinical and pathological features have important therapeutic implications.

Methodology Through the observation of a patient with Sertoli-Leydig cell tumor and a review of the literature, we tried to identify the main diagnostic and prognostic features.

Results Mrs.

TA, 31 years old, operated on for a benign nodule of the left breast, with no cycle disorder or signs of virilization and with well-developed secondary sexual characteristics, who was found on ultrasound, as part of the exploration of her 1-year primary infertility, a 3 cm solid cystic septated tumor of the right ovary, persistent. The dosage of CA 125, CEA and alpha-feto protein were not elevated. A laparoscopic intraperitoneal cystectomy was performed with peritoneal cytology. Histological and immunohistochemical examination concluded to a well-differentiated sertoli cell tumor. The operation was completed by a right adnexectomy. Two months later, the anatomopathology did not reveal any tumor recurrence. Postoperative monitoring, a reference biological workup including the dosage of DHEA-S, estrogen, testosterone, 17 hydroxy-progesterone and cortisol came back normal. The last clinical, ultrasonographic and biological controls carried out every three months, after a 1-year follow-up, did not show any recurrence.

Conclusion In the presence of pelvic pain associated with signs of hyperandrogenism, the diagnosis of a Sertoli-Leydig cell ovarian tumour should be considered. Pelvic ultrasound reveals an unilateral pelvic tumour, of solid cystic type. This tumor has a low malignant potential. Its treatment is based on surgery, which ranges from conservative treatment, justified in young women, to radical treatment indicated in advanced stages and in the presence of poor prognostic risk factors, which sometimes indicates adjuvant chemotherapy.

Disclosures The findings are specific to the study population and may not be generalizable to all ases of this type of tumor.

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.