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#686 Breast cancer in men: epidemiological and histo-pathological characteristics
  1. Jbir Ichraf1,
  2. Nouha Ben Ammar1,
  3. Salma Ben Othmen1,
  4. Houda Bel Fekih2 and
  5. Hassen Touinssi2
  1. 1Salah Azaiez Institute, Tunis, Tunisia
  2. 2Mohamed Taher Maamouri Hospital of Nabeul, Tunisia, Nabeul, Tunisia


Introduction/Background Cancer of the breast in men is an infrequent but serious problem. This study aimed to highlight this rare tumor’s clinical histological, prognostic, and therapeutic features.

Methodology We conducted a retrospective study of six male patients whose data were collected at Mohamed Taher Maamouri Hospital of Nabeul, Tunisia from January 2014 to December 2019.

Results Six cases were diagnosed. The average age was 53; the range was 27–63. The mean consultation time was 5 months, self-exam of a nodule was the main reason for consultation in 5 cases. Phenotype profiles were distributed as follows: luminal A (66.7%), luminal B (33.3%). The lesions were classified ACR 5 in 83.3%.

Stage T2 was predominantly observed (50%). The tumors were classified as N1 in 66.3% of cases. None of the patients had metastasis at diagnosis.

All patients had infiltrating ductal carcinoma. The mean histological size was 23.33 mm. SBR grade II was the most prevalent (66.7%). Histological lymph node involvement was observed in 33.3% of cases.

All of the patients had radical breast surgery, Radiotherapy, and hormonotherapy. Four patients had adjuvant chemotherapy.

The mean follow-up time was 37 months, patient‘s evolution was characterized by complete remission in 4 patients (66.7%), local recurrence, and metastatic recurrence in 2 patients (33.3%). In these two cases, Metastases occurred in the bones, the lungs, and the liver.

Overall survival and progression-free survival at 3 years were 83.3% and 66.7% respectively.

Conclusion Using adjuvant chemotherapy along with tamoxifen after surgery could potentially improve survival rates. Public education should be oriented toward men at higher risk to reduce the interval between the appearance of symptoms and consultation.

Disclosures Breast cancer in men is similar to breast cancer in women. However, there are distinct features that should be appreciated.

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