Introduction/Background Although skull base metastases from breast cancer are not uncommon, there are relatively few reported cases in the literature.

Methodology We report a case of clivus metastasis from breast cancer resulting in tongue fasciculations and dysarthria.

Results A 62-year-old woman followed since the age of 44 for left breast carcinoma classified as T2N1M0 treated by radical surgery with pathological examination: it is an infiltrating lobular carcinoma of 25 mm, receptors hormone positive, 5N+/10N. Treatment was continued with adjuvant chemotherapy followed by left locoregional radiotherapy at a dose of 50 Gy in 25 fractions. After 15 years of follow-up, the patient consulted an ENT doctor for pain in the tongue, followed by fasciculations, aphasia, and dysarthria. The patient was referred to our hospital for a detailed examination and treatment. PET-CT and cranial MRI detected a metastatic lesion to the clivus and the upper and dorsal cervical vertebrae. The clinical case was presented in a multidisciplinary meeting and the decision was to prescribe bisphosphates and perform palliative radiotherapy. Irradiation of the clivus from the cranial base to the second cervical spine at a dose of 20 Gy in 5 fractions using a conformal technique was carried out. Symptoms such as fasciculations and dysarthria have markedly regressed, and the patient is currently being followed at our consultation regularly.

Conclusion Bone metastasis of breast cancer worsens the quality of life and increases the mortality of patients. Current treatments for bone metastasis are only palliative, and efficient therapeutic targets need to be still identified.

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Abstract #98 Figure 1

Radiotherapy planning Of the Clivus metastasis

Disclosures The rate of metastasis to uncommon sites of breast cancer is on the rise due to the more effective therapy prolonging survival and the early detection on imaging.