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#1088 Granulosa cell tumors: clinical features, treatment challenges, and prognostic considerations
  1. Sirine Bayar1,
  2. Asma Jallouli1,
  3. Mahdi Farhati1,
  4. Abir Karoui1,
  5. Khawla Magdoud2,
  6. Badis Channoufi3 and
  7. Hassine Sabeur Abouda1
  1. 1The Center of Maternity and Neonatology in Tunis,Department C, Tunis, Tunisia
  2. 2The Center of Maternity and Neonatology in Tunis, Emergency Department, Tunis, Tunisia
  3. 3The Center of Maternity and Neonatology in Tunis, Department C, Tunis, Tunisia


Introduction/Background Granulosa-cell tumors(GCT) are a type of ovarian tumor that accounts for a small percentage of malignant ovarian tumors. They can be classified into adult and juvenile forms, with the adult form being more common. Diagnosis is based on anatomopathological examination, and GCTs are known for their slow and indolent progression. This study aims to describe the epidemiological, pathological, and clinical features of GCTs and identify prognostic factors to guide treatment decisions.

Methodology This retrospective study included twelve cases of adult GCTs managed at a Gynaecology and Obstetric department in Tunis between January 2007 and December 2015.

Results The average age of the subjects was 45 years, with 86% being non-menopausal women. The main diagnostic circumstances were abdominal pain, vaginal bleeding, and pelvic mass. A pelvic mass was found during the clinical examination in 10 cases.Ultrasound was the most commonly used investigation, revealing a large unilateral solid and cystic mass in 8 out of 12 cases. Magnetic Resonance Imaging (MRI) was also used, showing a solid mass with a cystic component in 7 cases. Hormonal markers, specifically CA125,were measured in only 4 cases.All patients underwent surgery, with one patient undergoing conservative surgery and nine patients undergoing limited staging procedures. Lymphadenectomy was performed in two cases. Intraoperative frozen section analysis was performed in 5 cases, showing discordance with subsequent histopathological examination in one case. Three patients received adjuvant chemotherapy using the BEP(Bleomycin, Etoposide, Cisplatinum) protocol.The median follow-up period was 16.87 months, during which one patient experienced pelvic recurrent disease after 4 years, and one patient died due to the disease.

Conclusion granulosa cell tumors have a slow progression and require accurate diagnosis through expert examination. Treatment involves surgery, but there is no consensus on adjuvant therapies.Improved tumor markers are needed for assessing aggressiveness and monitoring for recurrence, enhancing prognosis.

Disclosures The findings presented in this study are based on a retrospective analysis of clinical data and should be interpreted with caution.

Further research and prospective studies are warranted to validate these results and establish more definitive conclusions in the field of granulosa cell tumors.

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