Introduction/Background Hyperthermic intraperitoneal chemotherapy (HIPEC) has improved survival in advanced epithelial ovarian cancer (EOC) in randomised controlled trials when administered with interval debulking surgery (IDS). There is limited data on IDS HIPEC in EOC from India. This study aimed to assess the perioperative and survival outcomes of IDS HIPEC in Indian women with EOC.

Methodology In this prospective observational study, women who underwent IDS HIPEC for advanced EOC between March 2018 and December 2022 at Tata Medical Center were included. HIPEC (cisplatin 100 mg/m2) was offered to eligible women as per institutional protocol and multidisciplinary team recommendation. The Clavien-Dindo classification and Common Terminology Criteria for Adverse Events (CTCAE) version 5.0 were used for complications. Appropriate descriptive and survival statistics were used in the analysis.

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Abstract #832 Figure 1

Overall Survival

Results A total of 77 women (median age 54; IQR 46–63) underwent IDS HIPEC during the study period. The majority had stage IIIC (92.2%) and high-grade serous histology (94.8%). All had optimal cytoreduction at IDS (CC0 94.8%, CC1 5.2%) before HIPEC. Bowel resection and diversion rates were 20.8% and 11.7%, respectively. Surgical complications of Clavien-Dindo grade 3 or higher occurred in 19.5% of patients. CTCAE grade 3 or higher anaemia and hypokalaemia developed in 32.5% and 13%, while 39% had postoperative infections. Thirty-day readmission and 30-day death rates were 19.5% and 3.9%, respectively. The median hospital stay was 11 days (IQR 8–13) and the median time to adjuvant chemotherapy was 30 days (IQR 25–35). The median progression-free survival was 26.4 months (95% CI 22.4–30.4), and the median overall survival was 43.7 months (95% CI 37.7–49.8).

Conclusion HIPEC administered at the time of IDS in women with advanced EOC had acceptable safety and encouraging survival outcomes.

Disclosures none