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#732 Borderline ovarian tumor in pregnancy: a systematic review
  1. Tommaso Difonzo1,
  2. Vera Loizzi2,3,
  3. Francesca Arezzo1,
  4. Michele Mongelli1,
  5. Pietro Quarto1,
  6. Gaia Battista1,
  7. Massimiliano Memmola1,
  8. Anila Kardhashi2,
  9. Ambrogio Cazzolla2,
  10. Erica Silvestris2,
  11. Lorenzo Vinci1,
  12. Giulia Maria Contaldo1,
  13. Brunella Pilato2 and
  14. Gennaro Cormio2,3
  1. 1University of Bari, Bari, Italy
  2. 2IRCCS Istituto Tumori Giovanni Paolo II, Bari, Italy
  3. 3Department of Interdisciplinary Medicine, Bari, Italy


Introduction/Background Borderline ovarian tumors (BOT) discovered during pregnancy are rarely encountered. Despite the limitations of diagnostic procedures in pregnancy, BOTs must be differentiated from other ovarian masses for proper management and eventually prompt surgery. The purpose of this systematic review is to collect data that may be useful for future studies or management guidelines.

Methodology A systematic review was conducted to evaluate the clinical and histopathological features. The review was performed in accordance with the PRISMA statement. No restrictions on the publication period have been applied. Articles in English were considered eligible.

Results The literature search identified 12 relevant reports for a total of 76 cases. The data was collected from articles published from 1988 to 2022. The average age was 31 (range 20–45). All the patients were asymptomatic except for four case. Abdominal surgery was performed in 51 cases (including 20 cesarean sections), laparoscopy was performed in 19 cases and 6 cases underwent both laparotomy and laparoscopy. Among the unilateral BOT cases, there were 34 cases of cystectomy and 27 cases of unilateral salpingo-oophorectomy. Regarding histology, 35 cases (46%) were serous, 27 cases (35.5%) were mucinous, 11 cases (14.5%) were seromucinous and 3 cases were endometrioid (4%). Sixty-eight cases (89.5%) were stage I, 4 cases (5.25%) were stage II, and 4 cases (5.25%) were stage III. After the initial surgery, observational follow-up was performed in 48 cases, whereas 28 cases required additional treatment (22 cases of fertility-preserving surgery and 6 cases of curative surgery). Recurrence was identified in 6 of the 76 cases. Only one case of recurrence was observed among patients who underwent restaging surgery, whereas 5 cases of recurrence were noted in patients with observational follow-up.

Conclusion Nowdays there is not enough data to choose a unique clinical management and a standardized type of surgical treatment for BOT in pregnancy.

Disclosures No disclosures

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