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Abstract
Introduction/Background There are no set specific criteria to select Advanced Ovarian Cancer (AOC) patients for Cytoreductive Surgery (CRS). Therefore, the use of CT PCI as a tool for selecting AOC patients for CRS was explored.
Previous studied noted that preoperative assessment of patients with AOC with CT PCI for selecting patients for debulking surgery could be considered and described as useful.
Methodology A-double blinded prospective cohort study was carried out involving patients presenting to the University Hospitals of Leicester with AOC and undergoing CRS. The aim of the study was to investigate the agreement and the correlation between CT PCI and intra-operative PCI in AOC patients. Moreover, to identify the effect of CRS on the quality of life of AOC patients.
Results Surgical PCI was higher than the preoperative CT PCI. Pearson coefficient between the CT PCI and surgical PCI was found to be 0.492 (p= 0.011). This indicated a poor correlation between the CT and surgical PCI. Furthermore, the Intraclass Correlation Coefficient was 0.363 and showed that the level of agreement between the CT PCI and surgical PCI was poor.
Bland Altman test (figure 1) for preoperative CT PCI and surgical PCI was done. The mean difference between preoperative CT PCI and surgical PCI was -5.2 (95% confidence interval, -17.5 to 7.1) which indicates that preoperative CT PCI measures on average 5.2 lower than surgical PCI.
The overall global health status showed a non significant decrease from 64.5 prior to to 53.1 after the procedure (p=0.074). The physical functions, role functioning and social functioning has demonstrated a significant decline 3 months after cytoreductive surgery.
Bland altman for preoperative CT PCI and surgical PCI
Conclusion CT is not reliable in predicting intraoperative PCI in patients with high volume disease undergoing CRS. Further studies are needed to explore the effect of neoadjuvant chemotherapy on the precision of CT PCI in AOC patients.
Disclosures None