Introduction/Background Although the prognostic value of immune infiltrate has been extensively explored in HGSOC, very few studies explored it according to platinum-sensitivity/resistance status, an important factor for stratifying subsequent therapy.
Methodology Here, we questioned the prognostic value of 5 immune cell subsets (CD3+ and CD8+ T cells, FoxP3+ regulatory T cells, CD68+ and CD163+ tumor-associated macrophages) identified by immunohistochemistry in high-grade serous ovarian carcinoma using a clinically annotated tissue-microarray of 134 tumor samples.
Results We found that high intra-epithelial CD3+ T cell in tumor core was significantly associated with prolonged OS in all patients (HR=0.53; 95% CI [0.3–0.88]; p=0.03), and those who had platinum-sensitive disease (HR=0.51; 95% CI [0.27–0.94]; p=0.03). Similarly, a high density of CD68+ TAMs in tumor core was significantly associated with better OS in all patients (HR=0.49; 95% CI [0.27–0.91]; p=0.02), and those who had platinum-sensitive disease (HR=0.46; 95% CI [0.24–0.89]; p=0.02). Unexpectedly, there was a trend toward better survival in platinum-resistant patients who had stromal accumulation of FoxP3+ Treg (HR=0.27; 95% CI [0.06–1.15]; p=0.08).
Conclusion A deeper spatial and phenotypical characterization of tumor immune microenvironment in HGSOC according to platinum-sensitivity/resistance status is warranted for tailoring precision immunotherapy in this deadly disease.
Disclosures Together, our findings suggest that the prognostic value of immune infiltrate in HGSOC differs according to platinum-sensitivity/resistance status.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.