Introduction/Background The aim of this study was to investigate the role of prognostic nutritional index (PNI) in patients with high-grade serous ovarian cancer (HGSOC) and its relationship with other prognostic factors.

Methodology This retrospective study was conducted on 332 patients. The age range, body mass index (BMI), menopausal status, parity status, presence of comorbidities, American Society of Anesthesiologists (ASA) scores, the presence of ascites, cancer antigen 125 (CA-125), neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, disease stage, recurrence status, platinum resistance, attainment of optimal cytoreduction, and PNI were evaluated. PNI relationship with other factors affecting prognosis was evaluated.

Results The mean follow-up was 61.3 months. The mean PNI was 41.8 ± 8.7. PNI cutoff was 44.6 and lower PNI predicted shorter survival and higher mortality (96.84% sensitivity and 81.69% specificity-p<0.001 for each parameter). The PNI was significantly lower in patients with postmenopausal status, suboptimal cytoreduction, advanced-stage disease, platinum-resistance, ascites >1 L, recurrence, and a shorter 5-year survival rate. It has been determined that PNI ≤44.46 increases mortality (OR=136.821, 95% CI 54.6–342.4) (p<0.001) in patients with HGSOC.

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Abstract #526 Figure 1

Conclusion Prognostic nutritional index (PNI) is an important prognostic factor in high-grade serous ovarian cancer (HGSOC). PNI is a better predictor of mortality than CA-125 in HGSOC, and that low PNI is associated with high residual tumor burden, advanced stage disease, ascites and platinum resistance, recurrence, and shorter survival.

Disclosures None.