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#297 Prognostic factors among young women with epithelial ovarian cancer: the YOC-care study (young ovarian cancer – care)
  1. Leticia Azcona Sutil1,
  2. Marta Heras2,
  3. Octavio Arencibia3,
  4. Lucas Minig4,
  5. Maria Dolores Marti5,
  6. Andrea Baciu6,
  7. Juan Cespedes7,
  8. Isabel Ñiguez8,
  9. Blanca Gil-Ibañez9,
  10. Berta Diaz-Feijoo10,
  11. Lidia Maria Melero Cortes11,
  12. Josefina Marcos12,
  13. Jose Garcia-Villayzan13,
  14. Benjamina Gomez14,
  15. Manel Montesinos15,
  16. Sofia Herrero16,
  17. Juan Gilabert-Estelles17,
  18. Maria Fernandez-Chereguini18,
  19. Mikel Gorostidi19 and
  20. Ignacio Zapardiel20
  1. 1Hospital Virgen Macarena, Sevilla, Spain
  2. 2Hospital Universitario Santa Cristina, Madrid, Spain
  3. 3Hospital Universitario Materno Infantil, Gran Canaria, Spain
  4. 4IMED Hospital, Valencia, Spain
  5. 5Hospital Universitario Bellvitge, Barcelona, Spain
  6. 6Hospital Universitario La Paz, Madrid, Spain
  7. 7Hospital Universitario de Donostia, San Sebastian, Spain
  8. 8Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain
  9. 9Hospital 12 de Octubre, Madrid, Spain
  10. 10Hospital Clinic, Barcelona, Spain
  11. 11Hospital Virgen del Rocío, Sevilla, Spain
  12. 12Hospital General Universitario de Alicante, Alicante, Spain
  13. 13Fundación Jimenez Díaz, Madrid, Spain
  14. 14Hospital Virgen de la Arrixaca, Murcia, Spain
  15. 15Hospital La Fé, Valencia, Spain
  16. 16Hospital Puerta de Hierro, Madrid, Spain
  17. 17Hospital Universitario de Valencia, Valencia, Spain
  18. 18MD Anderson Cancer Center, Madrid, Spain
  19. 19Hospital Donostia, San Sebastian, Spain
  20. 20Hospital La Paz, Madrid, Spain


Introduction/Background Ovarian cancer is the most lethal of all gynaecological neoplasms in young women, affecting up to 10–15% of premenopausal women, however, there is very limited data on which are the most important prognostic factors

Methodology A multicentre and retrospective study was performed including women treated for epithelial ovarian cancer who were younger than 45 years old collected between January-2010 and December-2019. Borderline and non-epithelial ovarian cancers were excluded from the study

Results A total of 998 young patients with epithelial ovarian cancer from 55 different institutions in Spain were collected. The mean (standard deviation) age in the study population was 38.9 (5.8) years, and 853 (85.5%) presented an ECOG performance status grade 0 at diagnosis. The grouped FIGO stage distribution was 508 (50.9%) patients in initial stages (stages I and II) and 490 (49.1%) in advanced ones (stages III and IV). Three hundred thirty-four (33.4%) patients presented with recurrent disease after a mean follow up of 43.94 (SD 34.4) months. The type of staging surgery (incomplete vs. complete), the type of initial treatment modality (primary cytoreduction vs. interval surgery), and the amount of residual disease were all significantly associated with the overall survival. In the multivariate analysis, the response based on radiological findings (HR=3.91 95% CI 2.60–5.90 for partial response, HR=13.13; 95% CI 9.17–18.81 for progression), neoadjuvant chemotherapy (HR=1.81; 95%CI 1.32–2.46), and FIGO Stage (HR=1.68 95%CI 1.40–2.02) were identified as independent prognostic factors associated with the worst oncological outcomes (p<0.001)

Conclusion The radiology-based response, neoadjuvant chemotherapy and FIGO stage were independent prognostic factors associated with the worst oncological outcomes in women younger than 45 years old with epithelial ovarian cancer. It highlights the importance of primary complete cytoreduction, performing maximal-effort surgery in these patients due to the tumor´s characteristics and the better tolerance to maximal-effort cytoreduction in comparison to older women

Disclosures No

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