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#215 Retrospective re-evaluation of platinum-free interval and chemotherapeutic effect against subsequent platinum-containing chemotherapy in recurrent ovarian cancer patients initially treated by chemotherapy with bevacizumab
  1. Tamaki Tanaka1,
  2. Tomoka Usami2,
  3. Masako Ishikawa3,
  4. Eiji Kondo4,
  5. Masahiro Kagabu5,
  6. Kei Hirabayashi6,
  7. Noriomi Matsumura7,
  8. Shinya Sato8,
  9. Masato Nishimura9,
  10. Atsushi Arakawa10,
  11. Keiichiro Nakamura11,
  12. Yosuke Konno12,
  13. Kazuhiro Takehara13,
  14. Satoe Fujiwara14,
  15. Kotaro Sueoka15,
  16. Hiroko Nakamura16,
  17. Iemasa Koh17,
  18. Kimihiko Ito18 and
  19. Atsushi Hongo19
  1. 1Kagawa University Graduate School of Medicine, Kita, Kagawa, Japan
  2. 2Ehime University Graduate School of Medicine, Toon, Ehime, Japan
  3. 3Shimane University Faculty of Medicine, Izumo, Shimane, Japan
  4. 4Mie University Graduate School of Medicine, Tsu, Mie, Japan
  5. 5Iwate Medical University, Shiwa, Iwate, Japan
  6. 6JCHO Tokuyama Central Hospital, Syunan, Yamaguchi, Japan
  7. 7Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan
  8. 8Faculty of Medicine Tottori University, Yonago, Tottori, Japan
  9. 9Tokushima University, Tokushima, Japan
  10. 10Nagoya City University West Medical Center, Nagoya, Aichi, Japan
  11. 11Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
  12. 12Hokkaido University Hospital, Sapporo, Hokkaido, Japan
  13. 13National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime, Japan
  14. 14Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan
  15. 15Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
  16. 16NHO KURE Medical Center and Chugoku Cancer Center, Kure, Hiroshima, Japan
  17. 17Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
  18. 18Kansai Rosai Hospital, Amagasaki, Hyogo, Japan
  19. 19Kawasaki Medical School, Okayama, Japan


Introduction/Background It is concerned that the tumor dormancy effect of bevacizumab might prolong disease-free interval (DFI) regardless of platinum sensitivity, and lead to poorer outcome especially for patients recurrent in partially platinum-sensitive period defined as platinum free interval (PFI) of 6 to 12 months. We retrospectively investigated the relevance of PFI and response rate for recurrent ovarian cancer patients after chemotherapy with concurrent and maintenance bevacizumab.

Methodology Patients received platinum-based chemotherapy for platinum sensitive recurrent epithelial ovarian, fallopian tube and/or primary peritoneal cancer between November 1, 2013, and December 31, 2019, who initially had been confirmed complete response after platinum-based therapy with concurrent and maintenance bevacizumab, were registered. The primary endpoint was to examine response rate to subsequent chemotherapy after various period of PFI. The relevance between response rate and PFI divided into three groups of 6&lE;PFI<12, 12&lE;PFI<24 and PFI&gE;24 was assessed using Cochran-Armitage test. The secondary endpoint was progression-free survival (PFS) after chemotherapy for first recurrence, estimated separately for each three groups using the Kaplan-Meier method and differences between each group were evaluated with log-rank test. A P value <0.05 was considered statistically significant.

Results Total of 77 patients’ data were analyzed and the median PFI until first recurrence was 12 months (range: 6–43). The response rate of subsequent chemotherapy for patients with PFI of 6&lE;PFI<12, 12&lE;PFI<24 and PFI&gE;24 were 42%, 65% and 80%, which presented linear fashion increase (P<0.05, Cochran-Armitage test).

The results for partially platinum-sensitive patients were comparable to those of past reports.

Median PFS among three groups were 11 months (95%CI: 8.4–13.5), 13 months (95%CI: 5.4–20.5) and 8 months (95% CI: 6.7–9.2) (P=0.107, log-rank test), respectively.

Conclusion Although there was concern about prolongation of DFI unrelated to platinum sensitivity by adding bevacizumab for primary treatment, the relationship between PFI and response to subsequent platinum-based chemotherapy remained unchanged.

Disclosures N. Matsumura received grants support from AstraZeneca plc. and participate in speaker’s bureau sponsored by AstraZeneca plc., Takeda pharmaceutical Co., Ltd. and Chugai pharmaceutical Co., Ltd.

K. Takehara received grants support and honoraria fees from Chugai pharmaceutical Co., Ltd.

The other authors have no potential conflict of interest to report.

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