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#1060 The role of lymphadenectomy in endometrial stromal sarcoma
  1. Vid Janša,
  2. Branko Cvjeticanin,
  3. Špela Smrkolj,
  4. Nataša Kenda Suster,
  5. Luka Kovac,
  6. Matija Barbic,
  7. Marina Jakimovska Stefanovska,
  8. Kristina Drusany Staric,
  9. Mateja Lasic,
  10. Boštjan Pirš,
  11. Katja Jakopic Macek,
  12. Snježana Frkovic Grazio,
  13. Neža Lebic Belcijan,
  14. Borut Kobal and
  15. Leon Meglic
  1. University Medical Centre Ljubljana, Ljubljana, Slovenia


Introduction/Background Endometrial stromal sarcoma is a rare mesenchymal uterine neoplasms and represents less than 1% of all uterine malignancies. The role of lymphadenectomy in case of endometrial stromal sarcoma is controversial. According to literature the risk of node metastases ranges between 0 and 44%.

Methodology Retrospective study was conducted in a total of 16 patients treated in our institution between years 2016 and 2023. Patients with histologically proven uterine endometrial stromal sarcoma who underwent surgery were considered eligible for the analysis. Pelvic systematic lymphadenectomy or sentinel lymph node biopsy was performed based on the physician’s choice. Follow up and potential retroperitoneal recurrence of the disease was analysed.

Results From 2016 to 2023 16 women were surgically treated (7 low grade endometrial stromal sarcoma and 9 high grade endometrial stromal sarcoma) and only 5 patients underwent pelvic lymphadenectomy. In one case of high grade endometrial stromal sarcoma pelvic lymph nodes were positive, in all other cases lymph nodes were negative. In one case of high grade endometrial sarcoma the disease recurred after one year in pelvic lymph nodes. In all other cases there was no recurrence during follow up after surgical treatment, although there was no lymphadenectomy. In all cases of low grade endometrial stromal sarcoma, the lymph nodes were either negative in case of staging procedure or there were no signs of recurrence of the disease during follow up.

Conclusion According to literature and our data there is no indication to offer a systematic lymphadenectomy in apparent low-grade endometrial stromal. In case of high grade endometrial stromal sarcoma there is need for more studies aiming to determine the role of lymphadenectomy and sentinel lymph node biopsy. Retroperitoneal surgery should be limited in case of lymph nodes recurrences or primary pathological lymph nodes according to preoperative imaging or palpable intraoperative findings.

Disclosures No disclosures.

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