Introduction/Background Malignant diseases during pregnancy are rare conditions. The estimated incidence is around 1 per 1000 pregnancies. Each year 2500–5000 new cases are reported across Europe. Among these, both ovarian cancer and pancreatic cancer are extremely rare conditions. Pancreatic cancer with ovarian metastases can be easily misdiagnosed and most patients are first diagnosed as ovarian cancer.

Methodology We present the case of a patient with a pregnancy and osteoclast like giant cell pancreatic cancer misdiagnosed as advanced stage ovarian cancer.

Results The 36-year-old patient with an ovarian mass was presented to a regional hospital at the 20th week of pregnancy. Laparotomy was done with incomplete tumor reduction. The initial histology confirmed a high grade serous ovarian cancer. The patient was referred to our center. Based on imaging and histological findings and the age of pregnancy the patient received 3 cycles platinum based neoadjuvant chemotherapy. The extended radical cytoreductive surgery was performed at the 35th gestational week in one step with caesarean section. During the surgery complete tumor reduction was achieved with the resection of the pancreatic tail. The final histological examination diagnosed an undifferentiated osteoclast-like giant cell pancreatic adenocarcinoma, which is particularly rare especially during pregnancy. More than five years after the initial diagnosis the patient is tumor free.

Conclusion The treatment of cancer in pregnancy is quite complex and requires a multidisciplinary approach. Close monitoring of foetus under the treatment is extremely essential. Based on our review of the literature we didn’t identify similar case during pregnancy.

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Abstract #853 Figure 1

Disclosures The authors have no conflict of interest.