Introduction/Background Bacterial vaginosis (BV) is the most common vaginal disorder affecting women of reproductive age and has an influence in acquisition of certain genital infections. However, it is difficult to determine whether BV is actually a risk factor for human papilloma virus (HPV) acquisition or not and whether it may lead to cervical cancer.

Methodology A multiinstitutional prospective study was conducted to analyze the vaginal samples collected from the women aged between 19 and 49 years during the period from December 2014 to December2022. A total of 495 women with vaginal samples were analyzed for Bacterial Vaginosis(BV)9 (30.1%) samples were diagnosed with BV as per Amsel’s criteria. The prevalence of HPV DNA and CIN were studied in the same cohort. Results analysed and compared with BV positive and BV negative status.

Results A total of 495 women with vaginal samples were analyzed for BV. 149 (30.1%) samples were diagnosed with BV as per Amsel’s criteria. The prevalence of HPV DNA was higher in BV-positive cases in comparison to that of BV-negative cases (44.96% vs. 8.95%; P = 0.001) showing a significant association between BV and HPV infection. There was a rising trend in the incidence of CIN for women diagnosed with BV when compared to BV negative women (61.74% vs.42.19%; P = 0.506), although statistically insignificant. Moreover, the severity/high grading of CIN was not significantly associated with BV (P =0.321).

Conclusion The result of our study hypothesized that BV was significantly associated with increased risk of HPV infection. There was a rising trend in the association of BV with CIN incidence although statistically insignificant.

Disclosures Study was supported by grant from Department of Science and Technology, Odisha