Introduction/Background Cervical cancer is the third gynecological cancer arround the world and the first in some low income countries where it is one of the first women killers. Fertility is highly threatened by the surgical treatments, chemotherapy and pelvic radiation. The aim of this study is to report fertility after cervical cancer in women ≤40 in Tunisia

Methodology It is a retrospective study of a mono-centric database from January 2010 to January 2021. We evaluated the clinical history, treatment, follow-up, pregnancy and delivery of all women ≤40 diagnosed with cervical cancer, from a global cohort of 493 patients diagnosed in our center with cervical cancer during the same period.

Results We included 29 patients. The mean age was 34,7 ±4,7 years. Nineteen (82.6%) were married of whom 4 were nulliparous. The mean age of first sexual intercourse was 21.5 years [20–26]. The mean marriage duration was 12 years ±6.19. The mean age of the sexual partners was 40,3 ±5,29 years. According to the FIGO classification: 30.4% had non-invasive cancer and 18.6% had stage I. A fertility-sparing technique was proposed in 10 (43.4%) cases (9 conizations and a case of ovarian transposition prior to chemoradiation). After 5 years of follow up, 21.7% of women died of cervical cancer. Five patients (21.7%) expressed a desire for pregnancy after the treatment, one (4.3%) got pregnant spontaneously and had a cesarean section at 36 weeks of gestation. Five (21.7%) patients expressed that cervical cancer and its treatments had an impact on their sexuality and marital agreement.

Conclusion Fertility is a real issue of young women diagnosed with cervical cancer. Fertility sparing treatments are not a guarentee of parenthood in young cervical cancer survivals.

Disclosures Nothing to declare