Introduction/Background Anaplastic large cell lymphoma associated with a breast implant (BIA-ALCL) is a rare form of T-cell non-Hodgkin’s lymphoma first described in 1997 and officially recognized by the WHO in 2016. The diagnosis is made based on aspiration of the fluid around the implant and the positivity of the CD30 sample. In the world literature 3 cases of BIA-ALCL associated with pregnancy are described.

Methodology A 36-year-old woman with gestation age (GA) 26 weeks was admitted with pain in the left breast 5 years after bilateral augmentation. Upon admission, there were no obvious signs of neoplasia or lymphadenopathy. According to ultrasound of the mammary glands and regional lymph nodes, there were no changes outside the periprosthetic capsule. A fine-needle aspiration biopsy was performed. Immunocytochemical examination of periprosthetic fluid: tumor cells positive for CD30, CD4, CD2, negative for ALK, Pan SC (AE1/AE3), which corresponds to the diagnosis of BIA-ALCL. Ultrasound of the pelvic organs, abdominal cavity, MRI of the chest (non-contrast): bilateral seromas on the periphery of breast implants, absence of other pathological formations (stage IA according to the TNM classification) (figure 1). Surgical treatment with the explantation of endoprostheses and the surrounding fibrous capsule in a single block on both sides at 29 weeks GA.

• Download figure
• Open in new tab
• Download powerpoint

Abstarct #493 Figure 1

Anaplastic large cell lymphoma associated with a breast implant (BIA-ALCL) in a pregnant patient: Non-contrast chest MRI: bilateral seromas on the periphery of breast implants, with a large accumulation of fluid on the left

Results Dynamic monitoring with no signs of progression up to vaginal delivery (40 weeks GA) was performed. A healthy girl, Apgar 8/9, was born. Follow-up including 18F-FDG PET/CT was performed 3 and 12 months after delivery: no pathological changes were detected.

Conclusion The described case complements the limited available data on this topic, emphasizing that BIA-ALCL should be taken into account for diagnosis in the presence of spontaneous periprosthetic seroma with late onset even during pregnancy and that histological diagnostic signs of the disease do not differ in a pregnant woman.

Disclosures Nothing to disclose