Introduction/Background Fertility-sparing surgery is safe only if tumor doesn’t exceeded 2 cm in the biggest diameter. When the tumor bigger, surgery must be more radical (abdominal trachelectomy type C2), but pregnancy results aren’t promising. Neoadjuvant chemotherapy (NAC) followed by simple trachelectomy could be option.

Methodology Women with squamous cell, adeno and adenosquamous cancers IB2 and IB3 infiltrated less than two third of cervical stroma, were included to prospective study. They received 3 cycles of NAC in ten-days interval (cisplatin 75mg/m2, ifosfamide 2g/m2 (max. 3g) in squamous cancers, cisplatin 75mg/m2, doxorubicin 35mg/m2 in adeno and adenosquamous cancers). Women underwent sentinel lymph node mapping and laparoscopic pelvic lymphadenectomy. When lymph nodes were negative, simple trachelectomy were performed after one week.

Results Forty four women were included in to study(32 IB2 and 12IB3). Fertility was saved in 32 women (72.7%), five (15.6%) of them recurred (4local and 1 distant) and tree patient died (9.4%). Three women lost fertility after treatment of recurrence; definitively fertility was saved in 29 women. Twentyfour women want be pregnant until now and 22 (91.7%) became pregnant. Twenty women delivered 27 babies (tree in 24–27,five in 28–34,five in 34–36 weeks, fourteen in terms). One woman miscarried in first trimester, one in second trimester.

Conclusion Oncological results in NAC followed by simple trachelectomy in cervical cancers bigger than 2cm are acceptable (mortality rate 9.4%) and pregnancy results are excellent (pregnancy rate 91.7%), but still it is experimental protocol for full instructed women.

This work is supported Cooperatio program 207035, Maternal and Childhood Care, 3rd Faculty Medicine, Charles University

Disclosures This work is supported Cooperatio program 207035, Maternal and Childhood Care, 3rd Faculty Medicine, Charles University