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  • #1117 The prognostic characteristics and recurrence patterns of high grade endometrioid endometrial cancer: a large retrospective analysis of a tertiary center

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Poster/ePoster Sessions
03. Endometrial cancer
#1117 The prognostic characteristics and recurrence patterns of high grade endometrioid endometrial cancer: a large retrospective analysis of a tertiary center
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  1. Andreas Zouridis1,
  2. Kianoush Zarrindej2,
  3. Joshua Rencher3,
  4. Christina Pappa1,
  5. Ammara Kashif1,
  6. Sarah Louise Smyth1,
  7. Negin Sadeghi1,
  8. Alisha Alisha Sattar1,
  9. Stephen Damato1,
  10. Federico Ferrari4,
  11. Antonio Simone Laganà5,
  12. Mostafa Abdalla6,
  13. Sean Kehoe1,
  14. Susan Addley7 and
  15. Hooman Soleymani Majd1
  1. 1Oxford University Hospitals NHS Foundation Trust, Oxford, UK
  2. 2Buckinghamshire NHS Foundation Trust, Bucks, UK
  3. 3Royal Berkshire NHS Foundation Trust, Reading, UK
  4. 4Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy
  5. 5Unit of Gynecologic Oncology, ARNAS ‘Civico-Di Cristina-Benfratelli’, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy
  6. 6Gynaecology—Guy’s and St Thomas’ NHS Foundation Trust, London, UK
  7. 7University Hospitals of Derby and Burton NHS Foundation Trust, Derby, UK

Abstract

Introduction/Background High grade endometrioid endometrial cancer (HGEEC) is a heterogeneous group of tumors with unclear prognostic features. The aim of the present study is to evaluate the independent risk factors for recurrence and mortality and to describe the recurrence patterns of HGEEC.

Methodology Ninety-six consecutive cases of HGEEC treated with primary surgery in a single Tertiary Center were retrospectively reviewed. Clinicopathological and treatment details were recorded, and all patients were closely followed up.

Results Disease-free, overall and cancer-specific survival rates were 83.8%, 77.8% and 83.6%, respectively. Cervical stromal involvement was independently related to recurrence (HR = 25.67; 95%CI 2.95–223.30; p = 0.003) and cancer-related death (HR = 15.39; 95%CI 1.29–183.43; p = 0.031) after adjusting for other pathological and treatment variables. Recurrence rate was 16%, with 60% of these cases having lung metastases and only one case with single vaginal vault recurrence. 81.81% of the recurrences presented with symptoms and not a single recurrence was diagnosed in routine follow-up clinical examination.

Conclusion In conclusion, the recurrence pattern may suggest that patient-initiated follow-up (PIFU) could be considered a potential alternative to clinical-based follow-up for HGEEC survivors, especially for patients without cervical involvement and after two years from treatment. Additional caution is needed in patients with cervical stromal involvement.

Disclosures Authors have nothing to disclose

https://doi.org/10.1136/ijgc-2023-ESGO.417

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