Introduction/Background Isolated inguinal metastases from endometrial carcinoma are a rare occurrence and pose a challenge in the management of endometrial cancer.

Methodology In this study, we present the clinical outcomes and management of three cases with isolated inguinal metastases from endometrial cancer.

Results All three patients underwent total abdominal hysterectomy and bilateral pelvic lymphadenectomy.

The first patient was a 75-year-old woman with serous endometrial carcinoma, 88% myometrial invasion, lymphovascular space invasion, and FIGO Grade 2C. She experienced recurrence 6 months later, despite adjuvant chemotherapy.

The second patient was a 57-year-old woman with endometrial endometrioid cancer, 42% myometrial invasion,, lymphovascular space invasion negative and FIGO Grade 1A. She was diagnosed with recurrence 24 months later.

The third patient, also a 57-year-old woman with endometrial endometrioid cancer, had a metastatic lymph node, lymphovascular space invasion, 55% myometrial invasion with MELF pattern, and FIGO Grade 3C1i-macrometastasis. She received adjuvant radiotherapy and had recurrence 48 months later.

Conclusion The appearance of extra-abdominal metastases from endometrial cancer is rare, and the presence of isolated inguinal recurrences presents a unique challenge for the management of endometrial cancer. Careful follow-up and close monitoring are essential in identifying these rare occurrences and ensuring timely intervention.

Disclosures The authors received no financial support from any institution and there’s no conflict of interest.