Article Text

Download PDFPDF

#957 Sentinel lymph node biopsy with carbon dye for endometrial cancer staging: a single center, prospective, cohort study
  1. Yagmur Minareci,
  2. Hamdullah Sozen,
  3. Samet Topuz and
  4. Yavuz Mehmet Salihoglu
  1. Istanbul University, Faculty of Medicine, Department of Gynecology and Obstetrics, Division of Gynecologic Oncology, Istanbul, Turkey


Introduction/Background Endometrial cancer is the 4th most common cancer in women. Systematic lymphadenectomy determines the disease stage and prognosis. Sentinel lymph node biopsy (SLNB) may be defined as a minimally invasive procedure compared to systematic lymphadenectomy. Many agents have been used for the detection of SLNB in endometrial cancer. Carbon dye, which has a powerful colored ability and high contrast due to its dark black color, makes the lymph nodes efficiently identified. This is the first study on the use of carbon dye during the SLNB procedure in endometrium cancer. Our aim was to evaluate the safety and efficacy of carbon dye in the detection of sentinel lymph nodes in endometrial cancer patients.

Methodology The present trial was designed as a single-center, prospective, cohort study. The data from 89 patients were collected for the present study between December 2021 – August 2022.

Abstract #957 Table 1

Sensitivity and specificity data of SLN8 with carbon dye

Results Of the 89 patients, bilateral pelvic lymphadenectomy and para-aortic lymphadenectomy were performed in 89 (100%) and 36 (40.5%), respectively. Two hundred nine sentinel lymph nodes were harvested (104 from the right side, 105 from the left side), and five of the 89 patients had positive nodes. Of the five patients with positive sentinel lymph nodes, three had micrometastasis, and one had isolated tumor cells. The sensitivity of the SLNB with carbon dye in detecting nodal metastatic disease was 97.8%. However, one patient with negative SLNB had a positive para-aortic lymph node with micrometastasis resulting in a negative predictive value of 98.8%.

Conclusion Carbon dye was an easy-to-use, cheap, and effective agent for SLNB with satisfying specificity and sensitivity rates. Carbon dye may be a promising tracer without the need for expensive and complex equipment &procedures, particularly for low-income countries. We will soon report a similar study comparing the results of carbon dye and ICG during SLNB in endometrial cancer patients.

Disclosures we declared that we have no conflict of interest

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.