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Abstract
Introduction/Background Background: It remains unclear whether patients with adenomyosis and non-endometrioid endometrial cancer (EC) have better overall survival rates than patients with non-adenomyosis and non-endometrioid EC. We aim to compare non-endometrioid EC survival in patients with or without histological proven adenomyosis.
Demographic characteristic findings and surgery type of patients
Pathological findings of patients
Methodology We identified all patients with consecutive diagnosis of non-endometrioid EC who underwent surgical staging at a single center between May 1998 and March 2023. Patients with insufficient clinical or surgical data were excluded from the study. The patients were divided into two groups as adenomyosis and non-adenomyosis group. Demographic characteristics and clinical findings such as age, BMI, menopausal status and pathologic variables like presence of adenomyosis, tumor grade, depth of myometrial invasion, lymphavascular space involvement, lymph node status, and distant spread were obtained hospital records
Results A total of 139 patients were enrolled, 40 (28.7%) in the adenomyosis group and 99 (71.3%) in the non-adenomyosis group. There was no significant difference among non-endometrioid type EC patients with and without adenomyosis as regards to patient demographic characteristics and final pathologic variables (p>0.05). There was no difference between the two groups in terms of recurrence time (p>0.05). In addition, over all survival was found to be statistically significantly higher in the non-endometrioid type EC group with adenomyosis than in the without (p=0.02)
Recurrence and survival time of patients
Conclusion The presence of adenomyosis in non-endometrioid type endometrial cancer was not associated with pathological variables such as myometrial invasion, tumor diameter and lymphovascular space involvement. Although the rates of disease-free survival and cancer-related death were similar, the overall survival rate was significantly higher in the presence of adenomyosis
Disclosures The authors disclosed no conflict of interest