Introduction/Background Endometrial carcinoma is the most common gynecological tumor and its prevalence has increased in recent years. The definitive diagnosis is made through histopathological study, usually obtained through endometrial biopsy, and sometimes through hysteroscopy, which is the gold standard for diagnosing endometrial carcinoma.

Methodology A retrospective analysis was conducted on patients who underwent endometrial cancer surgery at our center between 2021 and 2022. The diagnostic methods used in these patients, the results of endometrial biopsy, and the need for hysteroscopy were evaluated.

Results A total of 60 patients underwent surgery at our center between 2021 and 2022. Among them, 42 patients were diagnosed with endometrial carcinoma through Cornier cannula. In 11 cases, hysteroscopy was performed directly due to the inability to obtain endometrial biopsy samples through aspiration due to lack of access, cervical stenosis, or patient discomfort. In 4 cases, the Cornier sample was insufficient, so hysteroscopy was performed, which diagnosed endometrial adenocarcinoma. In 3 cases, the biopsy results were normal, and the definitive diagnosis was made through hysteroscopy. In all cases, hysteroscopy revealed a suspicious formation of endometrial neoplasia.

Conclusion Endometrial biopsy is a simple test that can be performed in the clinic when there is a diagnostic suspicion of endometrial carcinoma. In some cases, it may not be feasible, and in others, if the biopsy is unsatisfactory or negative, hysteroscopy should be performed, which is the gold standard for diagnosing endometrial cancer. The false-negative rate of endometrial biopsy in our center was 6,66%, and in all cases, hysteroscopy was performed due to clinical suspicion.

Disclosures No conflicts of interest.