Introduction/Background Endometrial Cancer is the commonest malignancy in women. Surgery is the mainstay of the treatment of endometrial cancer. Sentinel lymph node concept reduced the morbidity of the treatment especially in well differantiated and early stage diseases. Although sentinel lymph node mapping can be used in high grade endometrial cancer full staging is usullay preferred choice of the treatment by gynecologic oncologist. Serous and high grade endometrial malignancies have similar behavior with serous ovarian cancer. Since peritoneal dissemination is frequently observed in serous tumors laparoscopy should be performed prudently. In the current study we aimed to evaluate surgical outcomes of high grade endometrial cancer managed by laparoscopy and laparotomy.

Methodology The patients udervent staging surgery between 2018 and 2021 January were included to the study. Patients with high grade endometrial cancer that were achieved R-0 resection included to the study. A full staging procedure including hysterectomy, salpingoopherectomy, pelvic and paraaortic lymphadenectomy up to renal vein, omentectomy, peritoneal washing and peritoneal biopsy was performed. osThe patients were compared according to demographic, surgical and pathological variables.

Results Mean age was 61 and 66 in laparoscopy and laparotomy groups respectively. Median CA 125 was 16 and 10 in the LS and LT groups. Preoperative tm diameter, opereation time, pelvic and paraaortic lymph node count, hospital stayi postoperative complications includeing bowel, urinary system and pulmonary system were similar. Stage were also between LS and LT groups. Survival analysis revealed no difference in terms of overall survival between LS and LT groups. (log rank p>0.05).

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Abstract #662 Figure 1

Conclusion Our study suggested that laparoscopic staging for high grade endometrial cancer has similar surgical and survival outcomes with laparotomy

Disclosures none