Introduction/Background We present a Triple neoplasm case to diagnose and raise awareness about other primary cancers that may develop after primary cancer.

Methodology A retrospective case was demonstrated.

Results 56 years patient has comorbidities of asthma, hypothyroidism, hypertension.During the breast cancer screening, the patient underwent USG and the right breast was reported as BI-RADS 3 and the left breast as BI-RADS 1. Tru-cut biopsy of the right breast resulted as IDC. Endometrial biopsy was performed because of concomitant anormal uterine bleeding, and it was concluded as Endometrıal Carcınoma. In the meantime, because of the thickening and heterogeneity of the gastric mucosa on MRI, malignancy was suspected and endoscopy was performed. Endoscopy results were reported as ‘differentiated adenocarcinoma’ in the lower end of the esophagus and ‘gastric adenocarcinoma’ in the cardia.First, segmental mastectomy was performed on the right breast, and biopsy was confirmed as IDC. Then Laparoscopic Hysterectomy- BSO -SLN was performed, the result was confirmed as Endometrıal Endometrıoıd Carcınoma. At this time, it was thought that gastric cancer might be an advanced stage peritoneal tumor, surgery was planned immediately after 4 cycles of neoadjuvant chemotherapy were given. After chemotherapy treatment, total gastrectomy - D2 dissection was performed and the biopsy result was confirmed as ‘gastric adenocarcinoma’. Letrozole added to treatment. The patient was discharged in good health and our follow-up continues.

Conclusion Until future studies incorporate the increased risk for certain types of neoplasm into appropriate guidelines, physicians should ensure that endometrial cancer survivors are counseled on this risk, while being screened not only for recurrence of the primary tumor but also for other types of cancer. It should be noted that; there may be patients who are successfully treated and followed up for endometrial carcinoma but are not adequately screened for subsequent neoplasms and remain undiagnosed until they reach an advanced stage.

Disclosures There is no conflict of interest in this statement.