Introduction/Background Endometrial cancer is the most prevalent gynecologic malignancy. Despite its generally favorable prognosis at primary diagnosis, recurrence of endometrial cancer remains an important clinical challenge.

The purpose of this study is to analyze the patterns of recurrence and the treatment options in the ‘real world’ setting.

Methodology A multicenter retrospective study endorsed by the Spanish Investigational Network Gynecologic Oncology Group (Spain-GOG) was performed. Patients with disease apparently confined in the uterus at the time of surgery, with histological confirmation of endometrial cancer after hysterectomy and bilateral salpingo-oophorectomy were assessed for eligibility. Finally, those patients who presented a recurrence during the follow-up period were included (468)

Results 468 out of 3618 patients from 15 centers presented a relapse (12.9%), with a mean follow-up period of 8.3 ± 3.6 years (range 3–13). Most of the recurrences presented an endometrioid histology (60.6%), followed by serous (17.5%) and carcinosarcoma (7,2%).

Distant recurrences (37.2%) were more frequently detected than local (25.4%), followed by carcinomatosis (19.6%) and lymphatic (17.3%). Regarding the local pattern recurrence 13.2% were in vaginal cuff and 12.2% were limited to pelvis.

Regarding the treatment 177 received chemotherapy (37.8%), 63 radioterapy (13.4%) and 19 both treatments; only 78 patients had surgery options (16.6%), and another 78 patients received palliative care (16.6%).

• Download figure
• Open in new tab
• Download powerpoint

Abstract #618 Figure 1

Pattern recurrence in endometrial cancer

Conclusion Between patients with a relapse, most of them presented disease not suitable for surgical treatment. Further studies are needed to elucidate treatments option for relapsed endometrial cancer not candidates for radical treatment

Disclosures No disclosure